The Roman Catholic Archdiocese of Santa Cruz de la Sierra is an ecclesiastical territory or diocese of the Roman Catholic Church in Bolivia. It was erected as the Diocese of Santa Cruz de la Sierra by Pope Paul V on July 5, 1605, and was elevated to the rank of a metropolitan archdiocese by Pope Paul VI on July 30, 1975, with the suffragan see of San Ignacio de Velasco.

Juan de Dios de Arguinao y Gutiérrez, OP was a prelate of the Catholic Church in the Viceroyalty of Peru. He served as bishop of Santa Cruz de la Sierra from 1646 to 1659, and as archbishop of Santafé in Nueva Granada from 1659 until his death in 1678.