The Roman Catholic Diocese of Cubao is a diocese of the western Latin Church of the Catholic Church in district of Cubao in Quezon City, in northern Metro Manila, Philippines. The diocese was created by Pope John Paul II on June 28, 2003 from the ecclesiastical district of Cubao of the Roman Catholic Archdiocese of Manila. It was canonically erected on August 28, 2003, with the installation of Honesto Flores Ongtioco as the first Bishop of Cubao. The Blessed Virgin Mary, under the title Immaculate Conception, is the principal patroness of the diocese.

The Parish of the Holy Sacrifice, also known as the Church of the Holy Sacrifice, is a landmark Roman Catholic chapel on the University of the Philippines Diliman campus. It belongs to the Roman Catholic Diocese of Cubao and its present parish priest is Rev. Fr. Jose S. Tupino III. More popularly known as the UP Chapel, the church was constructed under the supervision of Fr. John P. Delaney, who began ministering to the spiritual needs of the campus in 1947.