The Roman Catholic Diocese of Santiago de Veraguas is a suffragan diocese of the Archdiocese of Panamá. Appointed in April 2013, the current bishop is Audilio Aguilar Aguilar.

The Roman Catholic Metropolitan Archdiocese of Panamá is a Metropolitan Archdiocese, and its suffragan dioceses include Chitré, Colón-Kuna Yala, David, Penonomé and Santiago de Veraguas, as well as the Territorial Prelature of Bocas del Toro. The Diocese of Santa María de La Antigua del Darién was originally located upriver from the mouth of the Atrato River on the Gulf of Urabá in the Castilla de Oro province. The see was moved to Panama City and renamed as the Diocese of Panamá on 7 December 1520 and elevated to an archdiocese on 29 November 1925. The current Metropolitan Archbishop of Panama is Archbishop Jose Domingo Ulloa Mendieta, O.S.A.