The Catholic Diocese of Zacatecas is suffragan diocese to the Archdiocese of San Luis Potosí, in Mexico. Until 25 November 2006 it was a suffragan of the Archdiocese of Guadalajara, in Guadalajara, Mexico,.

The Mexican Catholic Church, or Catholic Church in Mexico, is part of the worldwide Catholic Church, under the spiritual leadership of the Pope, his Curia in Rome and the national Mexican Episcopal Conference. According to the Mexican census, Roman Catholicism is the dominant religion in Mexico, practiced by 77.7% of the population in 2020. A Statistica survey suggests this number could be lower, suggesting Catholics could make up only 72% of the nation.