The Rome–Ancona railway is a rail line in central Italy connecting the city of Ancona with Orte, and therefore with the capital city, Rome. The line crosses the Apennine Mountains from the Adriatic Sea to the Tyrrhenian Sea, passing through Foligno, Spoleto, and Terni.

Orte is a town, comune, former Catholic bishopric and Latin titular see in the province of Viterbo, in the central Italian region of Lazio, located about 60 kilometres (37 mi) north of Rome and about 24 kilometres (15 mi) east of Viterbo.