Rosecrans Avenue is a major west-east thoroughfare in Los Angeles and Orange Counties, California, USA. It has a total length of 27.5 miles (44.3 km). The street is named after U.S. Union General William S. Rosecrans, who purchased 13,000 acres (5,300 ha) of Rancho Sausal Redondo southwest of Los Angeles in 1869. Rosecrans Avenue was originally named Drexel Avenue, and ran through the Rosecrans Rancho which is part of modern-day Gardena.

Interstate 605 is a 27-mile-long (43 km) major north–south auxiliary Interstate Highway in the Greater Los Angeles urban area of Southern California. It runs from I-405 and State Route 22 (SR 22) in Seal Beach in Orange County to I-210 just south of the Irwindale–Duarte border in Los Angeles County. The San Gabriel River Freeway closely parallels the San Gabriel River for most of its alignment, hence its name, which is one of the few Southern California freeways not named after a city along its route.