Route 443 is also known as Ma'ale Beit Horon, following the ancient east-west trade route connecting the Via Maris and the Way of the Patriarchs. It is the main highway connecting Tel Aviv and Gush Dan with Jerusalem via Modi'in. While technically listed as a regional road, it is, for the most part, a divided, four-lane highway which utilizes some grade separation and interchanges, as well as major at-grade intersections, and thus is not classified as a motorway, even though there is a short motorway section on its western end, connecting it to westbound Highway 1.

Route 436 is a regional arterial road in Israel and the West Bank between Jerusalem and Givat Ze'ev. The southern portion begins as a major urban artery in Jerusalem's predominantly Hareidi neighborhoods leading to Highway 50, to Highway 1 and to the northern neighborhood of Ramot. Further north, the road runs alongside portions of Israel's West Bank Barrier as it approaches Givat Ze'ev. It crosses Route 443 to the Tel Aviv area and Highway 45 to Atarot and ends at the Beitunia section of the security barrier. The speed limit begins at 50 km/h along its urban section becoming 70 km/h as it passes through Ramot and then becoming 90 km/h as it leaves the Jerusalem municipality northwards. The road officially ends at the Beitunya cargo transfer terminal.