Maryland Route 54 (MD 54) and Delaware Route 54 (DE 54) are adjoining state highways in the U.S. states of Maryland and Delaware. Route 54 runs 41.84 mi (67.33 km) from MD 313 in Mardela Springs, Maryland, east to DE 1 in Fenwick Island, Delaware. In addition to two segments in which the highway is completely in Delaware and two segments in which the highway is completely in Maryland, Route 54 follows the Delaware/Maryland state line between the twin towns of Delmar, Maryland, and Delmar, Delaware, and the highway's intersection with MD 353 and DE 26. One section of the state line portion of Route 54 is maintained by the Delaware Department of Transportation (DelDOT) while three sections of the highway that follow the state line are maintained by the Maryland State Highway Administration (MDSHA).

U.S. Route 50 is a major east–west route of the U.S. Highway system, stretching just over 3,000 miles (4,800 km) from West Sacramento, California, east to Ocean City, Maryland, on the Atlantic Ocean. In the U.S. state of Maryland, US 50 exists in two sections. The longer of these serves as a major route connecting Washington, D.C., with Ocean City; the latter is the eastern terminus of the highway. The other section passes through the southern end of Garrett County for less than 10 miles (16 km) as part of the Northwestern Turnpike, entering West Virginia at both ends. One notable section of US 50 is the dual-span Chesapeake Bay Bridge across the Chesapeake Bay, which links the Baltimore–Washington metropolitan area with the Eastern Shore region, allowing motorists to reach Ocean City and the Delaware Beaches.