The Rowan County Regiment was originally established in about August 1, 1775 as a local militia in Rowan County in the Province of North-Carolina. When the North Carolina Provincial Congress authorized thirty-five existing county militias to be organized on September 9, 1775, the Rowan County Regiment was included and all officers were appointed with commissions from the Provincial Congress. The members of the Rowan County Regiment were mostly from what was Rowan County at the time. Prior to establishment of the Rowan County Regiment, many of its officers were active in the Rowan County Committee of Safety. The regiment included 160 known companies and one or more of these companies were engaged in 36 known battles or skirmishes during the American Revolution. After the establishment of the Rowan County Regiment, several other counties were created from Rowan County, including Burke County in 1777, Iredell County in 1788, Davidson County in 1822 and Davie County in 1836.

David Stewart Caldwell (1725–1824) was a Presbyterian minister, educator, physician, statesman, and early settler in Guilford County, North Carolina, in the mid 1700s.