Roxborough is a neighborhood in Northwest Philadelphia, Pennsylvania, United States. It is bordered to the southwest, along the Schuylkill River, by the neighborhood of Manayunk, along the northeast by the Wissahickon Creek section of Fairmount Park, and to the southeast by the neighborhood of East Falls. Beyond Roxborough to the northwest is Montgomery County. Roxborough's ZIP Code is 19128. Most of Roxborough is in Philadelphia's 21st Ward.

Northwest Philadelphia is a section of the city of Philadelphia. The official boundary is Stenton Avenue to the north, the Schuylkill River to the southwest, Northwestern Avenue to the northwest, Roosevelt Boulevard to the south, and Wister Street and Stenton Avenue to the east. Conventionally, the area east of Wissahickon Creek, which comprises Germantown, Mount Airy, Chestnut Hill, and Cedarbrook, is termed the 'Upper Northwest', and the area west of the creek, which comprises Roxborough, Wissahickon, East Falls, and Manayunk, is termed the 'Lower Northwest'. The area of Philadelphia west of the Schuylkill River is known as West Philadelphia. The Philadelphia Police Department patrols two districts located within Northwest Philadelphia. The two patrol districts serving Northwest Philadelphia are the 5th and 14th districts.