Roy Maurice Keane is an Irish football pundit and former professional player. He is the joint-most successful Irish footballer of all time, having won 19 major trophies, 17 of which came at Manchester United, in his club career, he served as the assistant manager of the Republic of Ireland national team from 2013 until 2018. Regarded as one of the best midfielders of his generation, in 2004 Keane was named by Pelé in the FIFA 100 list of the world's greatest living players. In 2007, The Times placed him at number 11 in their list of the 50 "hardest" footballers in history. In his 18-year playing career, Keane played for Cobh Ramblers, Nottingham Forest and Manchester United, before ending his career at Celtic. Keane was a dominating box-to-box midfielder, noted for his aggressive and competitive style of play, an attitude that helped him excel as captain of Manchester United from 1997 until his departure in 2005. Keane helped, he signed for Celtic, where he won a domestic double before he retired as a player in 2006.

Keane played at international level for the Republic of Ireland over a period of 14 years, most of which he spent as captain. At the 1994 FIFA World Cup, he played in every Republic of Ireland game, he was sent home from the 2002 FIFA World Cup after a dispute with national coach Mick McCarthy over the team's training facilities. Keane was appointed manager of Sunderland shortly after his retirement as a player and took the club from 23rd position in the Football League Championship, in late August, to win the division title and gain promotion to the Premier League, he resigned in December 2008, from April 2009 to January 2011, he was manager of Championship club Ipswich Town. In November 2013, he was appointed assistant manager of the Republic of Ireland national team by manager Martin O'Neill. Keane has worked as a studio analyst for British channel ITV's football coverage. Keane was born into a working class family in Ballinderry Park, Cork, his father, took work wherever he could find, which led to jobs at a local knitwear company and at Murphy's Irish Stout brewery, among others.

His family were keen on sport and many of his relatives had played for junior clubs in Cork, including Rockmount. Keane took up boxing at the age of nine and trained for a number of years, winning all of his four bouts in the novice league. During this period he was developing as a much more promising footballer at Rockmount, his potential was highlighted when he was voted Player of the Year in his first season. Many of his teammates were offered trials abroad with English football teams. Keane supported Celtic and Tottenham Hotspur as a child, citing Liam Brady and Glenn Hoddle as his favourite players, but as time progressed, Manchester United's Bryan Robson became the footballer he most admired. Keane was turned down from the Ireland schoolboys squad after a trial in Dublin. Undeterred, he began applying for trials with English clubs; as his childhood years passed, he took up temporary jobs involving manual work while waiting for a breakthrough in his football prospects. In 1989, he signed for the semi-professional Irish club Cobh Ramblers after persuasion from Ramblers' youth team manager Eddie O'Rourke.

Keane was one of two Ramblers representatives in the inaugural FAI/FAS scheme in Dublin, it was through this initiative that he got his first taste of full-time training. His rapid progression into a promising footballer was reflected by the fact that he would turn out for Ramblers' youth side as well as the actual first team playing twice in the same weekend as a result. In an FAI Youth Cup match against Belvedere, Keane's performance attracted the attention of watching Nottingham Forest scout Noel McCabe, who asked him to travel over to England for a trial. Keane impressed Forest manager Brian Clough, a deal for Keane worth £47,000 was struck with Cobh Ramblers in the summer of 1990. Keane found life in Nottingham difficult due to the long periods away from his family, he would ask the club for a few days' home leave in order to return to Cork. Keane expressed his gratitude at Clough's generosity when considering his requests, as it helped him get through his early days at the club. Keane's first games at Forest came in the Under-21s team during a pre-season tournament in the Netherlands.

In the final against Haarlem, he scored the winning penalty in a shootout to decide the competition, he was soon playing for the reserve team. His professional league debut came against Liverpool at the start of the 1990–91 season, the resulting performance encouraged Clough to use him more and more as the season progressed. Keane scored his first professional goal against Sheffield United, by 1991 he was a regular starter in the side, displacing the England international Steve Hodge. Keane scored three goals during a run to the 1991 FA Cup final, which Forest lost to Tottenham Hotspur. In the third round, however, he made a costly error against Crystal Palace, gifting a goal to the opposition and allowing them to draw the game. On returning to the dressing room after the game, Clough punched Keane in the face in anger, knocking him to the floor. Despite this incident, Keane bore no hard feelings against his manager claiming that he sympathised with Clough due to the pressures of management and that he was too grateful to him for giving him his chance in English football.

A year Keane returned to W

The Cú Chulainn Coaster is a wooden roller coaster located at Tayto Park in Ashbourne, County Meath, Ireland. Manufactured by The Gravity Group, the wooden coaster features an overbanked turn and opened on 6 June 2015; the Cú Chulainn Coaster was announced by Tayto Park in a press release on 19 February 2015, although construction started earlier in August 2014. Ohio-based company The Gravity Group was selected to build the roller coaster, marking their second installation in Europe following Twister at Gröna Lund in Sweden. Construction was completed in May 2015, the roller coaster opened on 6 June 2015, it was part of a €26 million investment at Tayto Park, which included 7 other new attractions for the 2015 season. Its theme is based on the mythological lore surrounding Irish hero Cú Chulainn, whom the ride is named after. Tayto Park official website

Walter Wagner was the notary who married Adolf Hitler to Eva Braun in the Führerbunker on 29 April 1945. Wagner was a lawyer who had joined the Nazi Party on 1 July 1931. In 1938 he was appointed acting head of the Central Legal Department in the Berlin Gau; this position was confirmed in January 1944 by Reichsminister Joseph Goebbels, acting in his capacity as Gauleiter of Berlin. Wagner represented Dr. Goebbels and the Berlin Gau in connection with the re-settlement of Berlin residents in Reichsgau Wartheland, a large area of Poland, annexed by the invading Nazi forces in 1939. Wagner carried out duties in that area from January 1943 to February 1944 and was based in Posen, the capital, where he not only met the local Governor, Arthur Greiser, but his future wife, Cordula Kroepels, an NSV social worker, involved in the re-settlement programme. Following their marriage on 10 March 1944 they moved to an apartment in Berlin-Buch where they lived together until October 1944. Wagner held a position with the local Pankow council as administrator of their refuse collection services.

In October 1944 Cordula, pregnant, left Berlin to live with her mother at Wyk auf Fohr where their son Michael was born on 1 November. In October 1944 Wagner joined the "Gauleitung" Battalion of the Berlin component of the Volkssturm, he continued living in his Berlin-Buch apartment together with his sister Gustl who last saw him in April 1945 when he was taken to the Führerbunker. In late April Hitler decided to marry Eva Braun and subsequently directed Goebbels to find a registrar who could carry out the ceremony. On 28 April Goebbels ordered the Waffen SS to bring him to the Führerbunker; the Waffen SS despatched a unit in an armoured personnel carrier to Wagner's home, only to find that he was fighting in the Friedrichstrasse area. Once located he was taken to the Führerbunker where he realised that the correct paperwork was not available; the armoured unit was obliged to take him back to Pankow where he found the correct documents. They returned to the Führerbunker. Wagner performed the ceremony just after midnight.

The event was witnessed by Martin Bormann. Afterwards Wagner left the Führerbunker and rejoined his unit. Wagner's unit was now charged with the defence of the Potsdamer Platz; the fighting was chaotic. Wagner's friend and company commander, Erich Illing, was wounded by Russian tank fire. Wagner, the Number 1 Section Commander assumed command of the company; as he continued the fight in the Anhalter Bahnhof area he was killed. It was less than 24 hours since he had married Eva Braun, his body was never found. In 1951 Wagner's widow, who had moved to Hamburg with the son he had never seen, wished to re-marry, she petitioned the Hamburg Court to issue a death certificate and, after submitting a number of affidavits from individuals, present at the time of Wagner's death, it was granted. In 1963 Stern magazine reported to the Hamburg Court that there were rumours circulating in Frankfurt that Wagner was living there; the court reopened the case. Gustl was questioned by a judge in Wyk and Cordula was interviewed in Mannheim.

The case was subsequently closed. Walter Wagner was an enigma. Plucked from obscurity at a critical moment in world history he enjoyed a few brief hours of fame before plunging back into obscurity and dying immediately afterwards in the Apocalypse, Berlin in April 1945. Both his Christian and surnames were common throughout Germany. However, as the notary who had married Hitler and Eva Braun his name appeared in every major work on the Battle of Berlin and Hitler's last days. However, although he was portrayed in many post war films, the real Walter Wagner remained a faceless individual until 2004 when the first photograph of him was published in Hitler and Women – The Love Life of Adolf Hitler, Ian Sayer & Douglas Botting Constable & Robinson London, 2004 ISBN 1-84119-918-4. In 1980 investigative writer Ian Sayer purchased a postcard, handwritten by Walter Wagner on 30 March 1945, it was addressed to his wife on the Frisian island of Fohr where she was living with his, as yet, unseen son. The stamp was a typical Nazi stamp bearing Hitler's effigy.

Someone had written at the top in another hand "The Last Card". Wagner's handwriting was so indecipherable. During the intervening period Sayer had attempted to locate any surviving members of Wagner's family. In 2002 he located Wagner's son, which prompted the publication of Hitler and Women which contained the first photograph of Wagner to be published. During his investigation Sayer had learned that Wagner's wife had been interrogated by British Intelligence at the end of the war to establish if she had heard from Wagner who had disappeared in Berlin, he was wanted for questioning in connection with the marriage of Eva Braun. The British Intelligence officer had sold it at auction 35 years later; the scene of Hitler's wedding is depicted in the films Hitler: The Last Ten Days, The Bunker and Der Untergang, all of which portray Wagner, in accordance with Nazi law, asking Hitler and Braun to confirm that they were of pure "Aryan" descent before the marriage can proceed. Walter Wagner has been portrayed by the following actors in film and television productions: Georg-Michael Wagner in the 1971 Eastern Bloc co-production Liberation: The Last Assault Andrew Sachs in the 1973 British

Ono Ranzan was a Japanese botanist and herbalist, known as the "Japanese Linnaeus". Ono was born in Kyoto to a courtly family, studied in his youth under Matsuoka Shoan. In 1754, he opened a school of botanical pharmacology which enjoyed considerable success, with over a thousand pupils enrolling. One student who studied under Ono at this time was Kimura Kenkadō. In 1799, he was given a post at the country's major government medical school in Edo. Here he worked extensively on a translation into Japanese of Rembert Dodoens' herbal guide, the Cruydeboeck. Ono was familiar with Western herbalism and had studied both traditional Chinese medicine and Western medicine as well; some of Ono's own works on Japanese botany were translated by the French botanist Ludovic Savatier. In the early years of the nineteenth century, Ono travelled around Japan gathering information on botanical remedies, which culminated in his most important literary work, the Honzō Kōmoku Keimō, published in 1803. Despite Ono's knowledge of Western and Chinese botany, this was one of the first books in the Japanese natural sciences to advocate experimentation and research rather than reliance on the Chinese Classics.

Ono never fathered a son with one of his household servants. His botanical work was continued by Ono Motoyoshi. After his death in 1810 he was interred at Asakusa; the barberry species Ranzania japonica was named in his honour

The Wallis WA-120 is an experimental British autogyro developed by Ken Wallis. Following on from his family of single-seat autogyros former Royal Air Force aviator Wing Commander Ken Wallis developed a high-performance long-range variant with an enclosed cockpit; the WA-120, registered G-AYVO, was first flown on 13 June 1971. The autogyro is powered by a 130 hp Rolls-Royce Continental O-240-A piston engine driving a four-bladed pusher propeller. Data from British Civil Aircraft since 1919 - Volume 3General characteristics Crew: 1 Length: 12 ft 0 in Main rotor diameter: × 20 ft 4 in Empty weight: 460 lb Gross weight: 750 lb Powerplant: 1 × Rolls-Royce Continental O-240-A, 130 hp Performance Cruise speed: 103 mph Range: 360 miles Related development Wallis WA-116 Agile Related lists List of rotorcraft

Computational biology involves the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological, ecological and social systems. The field is broadly defined and includes foundations in biology, applied mathematics, biochemistry, biophysics, molecular biology, genomics, computer science and evolution. Computational biology is different from biological computing, a subfield of computer science and computer engineering using bioengineering and biology to build computers, but is similar to bioinformatics, an interdisciplinary science using computers to store and process biological data. Computational biology, which includes many aspects of bioinformatics, is the science of using biological data to develop algorithms or models in order to understand biological systems and relationships; until biologists did not have access to large amounts of data. This data has now become commonplace in molecular biology and genomics.

Researchers were able to develop analytical methods for interpreting biological information, but were unable to share them among colleagues. Bioinformatics began to develop in the early 1970s, it was considered the science of analyzing informatics processes of various biological systems. At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms; this use of biological data to develop other fields pushed biological researchers to revisit the idea of using computers to evaluate and compare large data sets. By 1982, information was being shared among researchers through the use of punch cards; the amount of data being shared began to grow exponentially by the end of the 1980s. This required the development of new computational methods in order to analyze and interpret relevant information. Since the late 1990s, computational biology has become an important part of developing emerging technologies for the field of biology; the terms computational biology and evolutionary computation have a similar name, but are not to be confused.

Unlike computational biology, evolutionary computation is not concerned with modeling and analyzing biological data. It instead creates algorithms based on the ideas of evolution across species. Sometimes referred to as genetic algorithms, the research of this field can be applied to computational biology. While evolutionary computation is not inherently a part of computational biology, computational evolutionary biology is a subfield of it. Computational biology has been used to help sequence the human genome, create accurate models of the human brain, assist in modeling biological systems. Computational anatomy is a discipline focusing on the study of anatomical shape and form at the visible or gross anatomical 50 − 100 μ scale of morphology, it involves the development and application of computational and data-analytical methods for modeling and simulation of biological structures. It focuses on the anatomical structures being imaged, rather than the medical imaging devices. Due to the availability of dense 3D measurements via technologies such as magnetic resonance imaging, computational anatomy has emerged as a subfield of medical imaging and bioengineering for extracting anatomical coordinate systems at the morphome scale in 3D.

The original formulation of computational anatomy is as a generative model of shape and form from exemplars acted upon via transformations. The diffeomorphism group is used to study different coordinate systems via coordinate transformations as generated via the Lagrangian and Eulerian velocities of flow from one anatomical configuration in R 3 to another, it relates with shape statistics and morphometrics, with the distinction that diffeomorphisms are used to map coordinate systems, whose study is known as diffeomorphometry. Computational biomodeling is a field concerned with building computer models of biological systems. Computational biomodeling aims to develop and use visual simulations in order to assess the complexity of biological systems; this is accomplished through the use of specialized algorithms, visualization software. These models allow for prediction of; this is useful for determining. A robust biological system is one that “maintain their state and functions against external and internal perturbations”, essential for a biological system to survive.

Computational biomodeling generates a large archive of such data, allowing for analysis from multiple users. While current techniques focus on small biological systems, researchers are working on approaches that will allow for larger networks to be analyzed and modeled. A majority of researchers believe that this will be essential in developing modern medical approaches to creating new drugs and gene therapy. A useful modelling approach is to use Petri nets via tools such as esyN Computational genomics is a field within genomics which studies the genomes of cells and organisms, it is sometimes referred to as Computational and Statistical Genetics and encompasses much of Bioinformatics. The Human Genome Project is one example of computational genomics; this project looks to sequence the entire human genome into a set of data. Once implemented, this could allow for doctors to analyze the genome of an individual patient; this opens the possibility of personalized medicine, prescribing treatments based on an individual's pre-existing genetic patterns.

This project has created many similar programs. Researchers are looking to sequence the genomes o