The Royal Palace of Portici is a former royal palace in Portici, Southeast of Naples along the coast, in the region of Campania, Italy. Today it is the home of the Orto Botanico di Portici, a botanical garden operated by the University of Naples Federico II. These gardens were once part of the large royal estate that included an English garden, a zoo and formal parterres.

The University of Naples Federico II is a public research university in Naples, Campania, Italy. Established in 1224 and named after its founder, Frederick II, it is the oldest public, secular, non-sectarian or state-funded university in the world, and one of the world's ten oldest universities in continuous operation.