The Royal University of Ireland was founded in accordance with the University Education (Ireland) Act 1879 as an examining and degree-awarding university based on the model of the University of London. A royal charter was issued on 27 April 1880 and examinations were open to candidates irrespective of attendance at college lectures. The first chancellor was the Irish chemist Robert Kane.

A royal charter is a formal grant issued by a monarch under royal prerogative as letters patent. Historically, they have been used to promulgate public laws, the most famous example being the English Magna Carta of 1215, but since the 14th century have only been used in place of private acts to grant a right or power to an individual or a body corporate. They were, and are still, used to establish significant organisations such as boroughs, universities and learned societies.