The Royal University of San Felipe was a university created by King Philip V in 1738, in territory which was then part of the Kingdom of Spain. It was officially founded in Santiago in 1747 and began teaching activities in 1758. It is the immediate predecessor of the University of Chile (1843).

The University of Chile is a public research university in Santiago, Chile. It was founded on November 19, 1842, and inaugurated on September 17, 1843. It is the oldest in the country. It was established as the continuation of the former colonial Royal University of San Felipe (1738), and has a rich history in academic, scientific and social outreach. The university seeks to solve national and regional issues and to contribute to the development of Chile. It is recognized as one of the best universities in Latin America for its leadership and innovation in science, technology, social sciences, and arts through the functions of creation, extension, teaching, and research. It is considered the most important and prestigious university in the country.