Augustus Frederic Rudolf Hoernlé CIE, also referred to as Rudolf Hoernle or A. F. Rudolf Hoernle, was a German Indologist and philologist. He is famous for his studies on the Bower Manuscript (1891), Weber Manuscript (1893) and other discoveries in northwestern China and Central Asia particularly in collaboration with Aurel Stein. Born in India to a Protestant missionary family from Germany, he completed his education in Switzerland, and studied Sanskrit in the United Kingdom. He returned to India, taught at leading universities there, and in the early 1890s published a series of seminal papers on ancient manuscripts, writing scripts and cultural exchange between India, China and Central Asia. His collection after 1895 became a victim of forgery by Islam Akhun and colleagues in Central Asia, a forgery revealed to him in 1899. He retired from the Indian office in 1899 and settled in Oxford, where he continued to work through the 1910s on archaeological discoveries in Central Asia and India. This is now referred to as the "Hoernle collection" at the British Library.

The Bower Manuscript is a collection of seven fragmentary Buddhist Hybrid Sanskrit treatises found buried in a Buddhist memorial stupa near Kucha, northwestern China. Written in early Gupta script on birch bark, it is variously dated in 5th to early 6th century. The Bower manuscript includes the oldest dated fragments of an Indian medical text, the Navanitaka.