1.
Kensington
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Kensington is an affluent district within the Royal Borough of Kensington and Chelsea in West London. Its commercial heart is Kensington High Street, the affluent and densely populated area contains the major museum district of South Kensington, which has the Royal Albert Hall for music and nearby Royal College of Music. The area is home to many of Londons European embassies, the first mention of the area is in the Domesday Book of 1086, where it was written in Latin as Chenesitone, which has been interpreted to have originally been Kenesignetun in Anglo-Saxon. A variation may be Kesyngton, in 1396 and he in turn granted the tenancy of Kensington to his vassal Aubrey de Vere I, who was holding the manor in 1086, according to Domesday Book. The bishops heir, Robert de Mowbray, rebelled against William Rufus, Aubrey de Vere I had his tenure converted to a tenancy in-chief, holding Kensington after 1095 directly of the crown. He granted land and church there to Abingdon Abbey at the deathbed request of his young eldest son, Geoffrey. As the Veres became the earls of Oxford, their estate at Kensington came to be known as Earls Court, while the Abingdon lands were called Abbots Kensington and the church St Mary Abbots. The original Kensington Barracks, built at Kensington Gate in the late 18th century, were demolished in 1858, the focus of the area is Kensington High Street, a busy commercial centre with many shops, typically upmarket. The street was declared Londons second best shopping street in February 2005 thanks to its range, however, since October 2008 the street has faced competition from the Westfield shopping centre in nearby White City. Kensingtons second group of buildings is at South Kensington, where several streets of small to medium-sized shops. This is also the end of Exhibition Road, the thoroughfare that serves the areas museums. To the west, a border is kept along the line of the Counter Creek marked by the West London railway line, in the north east, the large Royal Park of Kensington Gardens is a green buffer. The other main area in Kensington is Holland Park, just north of Kensington High Street. Kensington is, in general, an affluent area, a trait that it now shares with its neighbour to the south. In early 2007, houses sold in Upper Phillimore Gardens for in excess of £20 million, Kensington is also very densely populated, it forms part of the most densely populated local government district in the United Kingdom. This high density is not formed from high-rise buildings, instead, unlike northern extremities of the Borough, Kensington lacks high-rise buildings except for the Holiday Inns London Kensington Forum Hotel in Cromwell Road, which is a 27-storey building. The Olympia exhibition hall is just over the border in West Kensington. Kensington is part of the Royal Borough of Kensington and Chelsea, the head office of newspaper group DMGT is located in Northcliffe House in Kensington, which is the office part of the large Barkers building
2.
United Kingdom
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The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom or Britain, is a sovereign country in western Europe. Lying off the north-western coast of the European mainland, the United Kingdom includes the island of Great Britain, Northern Ireland is the only part of the United Kingdom that shares a land border with another sovereign state—the Republic of Ireland. The Irish Sea lies between Great Britain and Ireland, with an area of 242,500 square kilometres, the United Kingdom is the 78th-largest sovereign state in the world and the 11th-largest in Europe. It is also the 21st-most populous country, with an estimated 65.1 million inhabitants, together, this makes it the fourth-most densely populated country in the European Union. The United Kingdom is a monarchy with a parliamentary system of governance. The monarch is Queen Elizabeth II, who has reigned since 6 February 1952, other major urban areas in the United Kingdom include the regions of Birmingham, Leeds, Glasgow, Liverpool and Manchester. The United Kingdom consists of four countries—England, Scotland, Wales, the last three have devolved administrations, each with varying powers, based in their capitals, Edinburgh, Cardiff and Belfast, respectively. The relationships among the countries of the UK have changed over time, Wales was annexed by the Kingdom of England under the Laws in Wales Acts 1535 and 1542. A treaty between England and Scotland resulted in 1707 in a unified Kingdom of Great Britain, which merged in 1801 with the Kingdom of Ireland to form the United Kingdom of Great Britain and Ireland. Five-sixths of Ireland seceded from the UK in 1922, leaving the present formulation of the United Kingdom of Great Britain, there are fourteen British Overseas Territories. These are the remnants of the British Empire which, at its height in the 1920s, British influence can be observed in the language, culture and legal systems of many of its former colonies. The United Kingdom is a country and has the worlds fifth-largest economy by nominal GDP. The UK is considered to have an economy and is categorised as very high in the Human Development Index. It was the worlds first industrialised country and the worlds foremost power during the 19th, the UK remains a great power with considerable economic, cultural, military, scientific and political influence internationally. It is a nuclear weapons state and its military expenditure ranks fourth or fifth in the world. The UK has been a permanent member of the United Nations Security Council since its first session in 1946 and it has been a leading member state of the EU and its predecessor, the European Economic Community, since 1973. However, on 23 June 2016, a referendum on the UKs membership of the EU resulted in a decision to leave. The Acts of Union 1800 united the Kingdom of Great Britain, Scotland, Wales and Northern Ireland have devolved self-government
3.
Fellow of the Royal Society
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As of 2016, there are around 1600 living Fellows, Foreign and Honorary Members. Fellowship of the Royal Society has been described by The Guardian newspaper as “the equivalent of a lifetime achievement Oscar” with several institutions celebrating their announcement each year. Up to 60 new Fellows, honorary and foreign members are elected annually usually in May, each candidate is considered on their merits and can be proposed from any sector of the scientific community. Fellows are elected for life on the basis of excellence in science and are entitled to use the post-nominal letters FRS, see Category, Fellows of the Royal Society and Category, Female Fellows of the Royal Society. Every year, Fellows elect up to ten new Foreign Members, like Fellows, Foreign Members are elected for life through peer review on the basis of excellence in science. As of 2016 there are around 165 Foreign Members, who are entitled to use the post-nominal ForMemRS, see Category, Foreign Members of the Royal Society. Honorary Fellows include Bill Bryson, Melvyn Bragg, Robin Saxby, David Sainsbury, Baron Sainsbury of Turville, Honorary Fellows are entitled to use the post nominal letters HonFRS. Others including John Maddox, Patrick Moore and Lisa Jardine were elected as honorary fellows, statute 12 is a legacy mechanism for electing members before official honorary membership existed in 1997. Fellows elected under statute 12 include David Attenborough and John Palmer, prime Ministers of the United Kingdom such as Margaret Thatcher, Neville Chamberlain, H. H. Asquith were elected under statute 12, see Category, Fellows of the Royal Society. The Council of the Royal Society can recommend members of the British Royal Family for election as Royal Fellows of the Royal Society. As of 2016 there are five royal fellows, Charles, Prince of Wales, Anne, Princess Royal, Prince Edward, Duke of Kent, Prince William, Duke of Cambridge and Prince Andrew, Duke of York. Her Majesty the Queen, Elizabeth II is not a Royal Fellow, Prince Philip, Duke of Edinburgh was elected under statute 12, not as a Royal Fellow. The election of new fellows is announced annually in May, after their nomination, each candidate for Fellowship or Foreign Membership is nominated by two Fellows of the Royal Society, who sign a certificate of proposal. Previously, nominations required at least five fellows to support each nomination by the proposer, the certificate of election includes a statement of the principal grounds on which the proposal is being made. There is no limit on the number of nominations each year. In 2015, there were 654 candidates for election as Fellows and 106 candidates for Foreign Membership. The final list of up to 52 Fellowship candidates and up to 10 Foreign Membership candidates is confirmed by the Council in April, a candidate is elected if he or she secures two-thirds of votes of those Fellows present and voting. A further maximum of six can be ‘Honorary’, ‘General’ or ‘Royal’ Fellows, nominations for Fellowship are peer reviewed by sectional committees, each with fifteen members and a chair
4.
Military Cross
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The Military Cross is the third-level military decoration awarded to officers and other ranks of the British Armed Forces, and used to be awarded to officers of other Commonwealth countries. The MC is granted in recognition of an act or acts of gallantry during active operations against the enemy on land to all members. In 1979, the Queen approved a proposal that a number of awards, including the Military Cross, the award was created on 28 December 1914 for commissioned officers of the substantive rank of Captain or below and for Warrant Officers. In August 1916, Bars were awarded to the MC in recognition of the performance of acts of gallantry meriting the award. In 1931 the award was extended to Majors and also to members of the Royal Air Force for actions on the ground, the MC now serves as the third-level award for gallantry on land for all ranks of the British Armed Forces. 46 mm max height,44 mm max width, ornamental silver cross with straight arms terminating in broad finials, suspended from plain suspension bar. Obverse decorated with crowns, with the Royal Cypher in centre. Reverse is plain, but from 1938 the name of the recipient, the ribbon width is 32 mm and consists of three equal vertical moire stripes of white, purple, and white. During World War I, Acting Captain Francis Wallington of the Royal Field Artillery was the first person to be awarded the MC, during World War II Captain Sam Manekshaw, Indian Army, was leading a counter-offensive operation against the invading Japanese Army in Burma. During the course of the offensive, he was hit by a burst of machine-gun fire, Major General D. T. Cowan spotted Manekshaw holding on to life and was aware of his valour in face of stiff resistance from the Japanese. Fearing the worst, Major General Cowan quickly pinned his own Military Cross ribbon on to Manekshaw saying, the first posthumous Military Cross was that awarded to Captain Herbert Westmacott, Grenadier Guards for gallantry in Northern Ireland during the period 1 February 1980 to 30 April 1980. The first woman to be awarded the Military Cross was Private Michelle Norris of the Royal Army Medical Corps, Norris was awarded her medal personally by Queen Elizabeth II on 21 March 2007 as the result of her actions in Iraq on 11 June 2006. Able Seaman Kate Nesbitt, second woman, first in the Royal Navy, sergeant Michael Lockett MC was the first holder of the MC to be killed in action since World War II. Database of Australian Awardees at the Australian Government Honours website Search recommendations for the Military Cross on The UK National Archives website, the Kings Own Royal Regiment Museum, Military Cross
5.
Fellow of the Royal Society of Edinburgh
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Fellowship of the Royal Society of Edinburgh is an award granted to individuals that the Royal Society of Edinburgh judges to be eminently distinguished in their subject. Around 50 new fellows are elected each year in March, as of 2016 there are around 1650 Fellows, including 71 Honorary Fellows and 76 Corresponding Fellows. Fellows are entitled to use the post-nominal letters FRSE, examples of fellows include Peter Higgs and Jocelyn Bell Burnell. Previous fellows have included Melvin Calvin and Benjamin Franklin, see the Category, Fellows of the Royal Society of Edinburgh for more examples
6.
London
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London /ˈlʌndən/ is the capital and most populous city of England and the United Kingdom. Standing on the River Thames in the south east of the island of Great Britain and it was founded by the Romans, who named it Londinium. Londons ancient core, the City of London, largely retains its 1. 12-square-mile medieval boundaries. London is a global city in the arts, commerce, education, entertainment, fashion, finance, healthcare, media, professional services, research and development, tourism. It is crowned as the worlds largest financial centre and has the fifth- or sixth-largest metropolitan area GDP in the world, London is a world cultural capital. It is the worlds most-visited city as measured by international arrivals and has the worlds largest city airport system measured by passenger traffic, London is the worlds leading investment destination, hosting more international retailers and ultra high-net-worth individuals than any other city. Londons universities form the largest concentration of education institutes in Europe. In 2012, London became the first city to have hosted the modern Summer Olympic Games three times, London has a diverse range of people and cultures, and more than 300 languages are spoken in the region. Its estimated mid-2015 municipal population was 8,673,713, the largest of any city in the European Union, Londons urban area is the second most populous in the EU, after Paris, with 9,787,426 inhabitants at the 2011 census. The citys metropolitan area is the most populous in the EU with 13,879,757 inhabitants, the city-region therefore has a similar land area and population to that of the New York metropolitan area. London was the worlds most populous city from around 1831 to 1925, Other famous landmarks include Buckingham Palace, the London Eye, Piccadilly Circus, St Pauls Cathedral, Tower Bridge, Trafalgar Square, and The Shard. The London Underground is the oldest underground railway network in the world, the etymology of London is uncertain. It is an ancient name, found in sources from the 2nd century and it is recorded c.121 as Londinium, which points to Romano-British origin, and hand-written Roman tablets recovered in the city originating from AD 65/70-80 include the word Londinio. The earliest attempted explanation, now disregarded, is attributed to Geoffrey of Monmouth in Historia Regum Britanniae and this had it that the name originated from a supposed King Lud, who had allegedly taken over the city and named it Kaerlud. From 1898, it was accepted that the name was of Celtic origin and meant place belonging to a man called *Londinos. The ultimate difficulty lies in reconciling the Latin form Londinium with the modern Welsh Llundain, which should demand a form *lōndinion, from earlier *loundiniom. The possibility cannot be ruled out that the Welsh name was borrowed back in from English at a later date, and thus cannot be used as a basis from which to reconstruct the original name. Until 1889, the name London officially applied only to the City of London, two recent discoveries indicate probable very early settlements near the Thames in the London area
7.
Wellington College, Berkshire
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Wellington College is a British co-educational boarding and day independent school in the village of Crowthorne, Berkshire. Wellington is a charity and currently has about 1,050 pupils aged between 13 and 18. It was built as a monument to the first Duke of Wellington. Her Majesty Queen Victoria laid the stone in 1856 and inaugurated the Schools public opening on 29 January 1859. Many former Wellington pupils fought in the straight after leaving school during the First World War, volunteering for military action. A further 501 former pupils were killed in action in the Second World War, the school is a member of the Rugby Group, which includes Harrow School and Charterhouse School, and is also a member of the G20 Schools group. The Good Schools Guide calls the school a serious player in the field of education, Wellington College was granted its royal charter in 1853 as the Royal and Religious Foundation of The Wellington College, and was opened in 1859. Its first Master was Edward White Benson, later Archbishop of Canterbury, the colleges Visitor is HM The Queen. Originally, the school supported children of deceased officers who had held commissions in the Army, in 1952 a Supplementary Royal Charter extended the privilege of eligibility to the orphan children of deceased officers of the Royal Navy, Royal Marines and Royal Air Force. However, only a minority of the children at the come from military families. By the 1950s and 1960s, the school was considering becoming co-educational, the first girls were admitted into the Sixth Form in the 1970s and the school became fully co-educational in 2005. Wellington has sponsored the founding of a new independent state school in Wiltshire, The Wellington Academy, Wellington is also partnered with Wellington College International Shanghai, in the city of Shanghai, now open. The college was designed by John Shaw, Jr. who had previously worked as an architect for Eton College. The main buildings were designed in a style loosely termed French Grand Rococo, there have been many modern buildings, the best of which follow Shaws style while still being modern, for example, the new Nicholson modern foreign-languages building. Wellington College stands on a 400-acre estate in South-East England, near Reading, the grounds of the college include a golf course and woodland in addition to playing fields. The grounds contain many unusual ant and spider species, and were frequented by the entomologist Horace Donisthorpe, the grounds also contain a Site of Special Scientific Interest, Wellington College Bog. Notable former pupils include historian P. J. Wellington College was one of the 21 founding members of the Rugby Football Union, Wellington have a national reputation for Rugby. In 2014/15 Wellington College 1st XV won the Rugby World School Team of the Year award and they also won the National Daily Mail Trophy title, as well as the Rosslyn Park National Schools 7s Open
8.
King's College London
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Kings College London is a public research university located in London, United Kingdom, and a founding constituent college of the federal University of London. Kings was established in 1829 by King George IV and the Duke of Wellington, in 1836, Kings became one of the two founding colleges of the University of London. It is a member of organisations such as the Association of Commonwealth Universities, the European University Association. Kings has five campuses, its main campus on the Strand in central London. In 2015/16, Kings had an income of £738.4 million, of which £193.2 million was from research grants and contracts and as of 2014/15. It has the fifth largest endowment of any university in the United Kingdom, and its academic activities are organised into nine faculties which are subdivided into numerous departments, centres and research divisions. Kings is home to six Medical Research Council centres and is a member of the Kings Health Partners academic health sciences centre, Francis Crick Institute. Kings College London, so named to indicate the patronage of King George IV, was founded in 1829 in response to the controversy surrounding the founding of London University in 1826. The need for such an institution was a result of the religious and social nature of the universities of Oxford and Cambridge, which then educated solely the sons of wealthy Anglicans. The secular nature of London University was disapproved by The Establishment, indeed, thus, the creation of a rival institution represented a Tory response to reassert the educational values of The Establishment. Winchilsea and about 150 other contributors withdrew their support of Kings College London in response to Wellingtons support of Catholic emancipation. In a letter to Wellington he accused the Duke to have in mind insidious designs for the infringement of our liberty, the letter provoked a furious exchange of correspondence and Wellington accused Winchilsea of imputing him with disgraceful and criminal motives in setting up Kings College London. The result was a duel in Battersea Fields on 21 March 1829, Winchilsea did not fire, a plan he and his second almost certainly decided upon before the duel, Wellington took aim and fired wide to the right. Accounts differ as to whether Wellington missed on purpose, Wellington, noted for his poor aim, claimed he did, other reports more sympathetic to Winchilsea claimed he had aimed to kill. Honour was saved and Winchilsea wrote Wellington an apology, duel Day is still celebrated on the first Thursday after 21 March every year, marked by various events throughout Kings, including reenactments. Kings opened in October 1831 with the cleric William Otter appointed as first principal, despite the attempts to make Kings Anglican-only, the initial prospectus permitted, nonconformists of all sorts to enter the college freely. William Howley, the governors and the professors, except the linguists, had to be members of the Church of England but the students did not, though attendance at chapel was compulsory. Kings was divided into a department and a junior department, also known as Kings College School
9.
Gonville and Caius College, Cambridge
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Gonville and Caius College is a constituent college of the University of Cambridge in Cambridge, England. The college is the fourth-oldest college at the University of Cambridge, the college has been attended by many students who have gone on to significant accomplishment, including fourteen Nobel Prize winners, the second-most of any Oxbridge college. The college has long associations with medical teaching, especially due to its alumni physicians, John Caius. Other famous alumni in the sciences include Francis Crick, James Chadwick, Stephen Hawking, previously Cambridges Lucasian Chair of Mathematics Emeritus, is a current fellow of the college. The college also maintains academic programmes in other disciplines, including economics, English literature. Gonville and Caius is said to own or have rights to much of the land in Cambridge, several streets in the city, such as Harvey Road, Glisson Road and Gresham Road, are named after alumni of the College. The college was first founded, as Gonville Hall, by Edmund Gonville, Rector of Terrington St Clement in Norfolk in 1348, when Gonville died three years later, he left a struggling institution with almost no money. The executor of his will, William Bateman, Bishop of Norwich, stepped in and he leased himself the land close to the river to set up his own college, Trinity Hall, and renamed Gonville Hall The Hall of the Annunciation of the Blessed Virgin Mary. Bateman appointed the first Master of the new college his former chaplain John Colton, by the sixteenth century, the college had fallen into disrepair, and in 1557 it was refounded by Royal Charter as Gonville and Caius College by the physician John Caius. John Caius was master of the college from 1559 until shortly before his death in 1573 and he provided the college with significant funds and greatly extended the buildings. During his time as Master, Caius accepted no payment but insisted on several unusual rules, Caius also built a three-sided court, Caius Court, “lest the air from being confined within a narrow space should become foul”. Caius did, however, found the college as a centre for the study of medicine. By 1630, the college had expanded greatly, having around 25 fellows and 150 students, since then the college has grown considerably and now has one of the largest undergraduate populations in the university. The college first admitted women as fellows and students in 1979 and it now has over 110 Fellows, over 700 students and about 200 staff. Gonville and Caius is one of the wealthiest of all Cambridge colleges with net assets of £180 million in 2014, the college’s present Master, the 42nd, is Alan Fersht. The first buildings to be erected on the current site date from 1353 when Bateman built Gonville Court. The college chapel was added in 1393 with the Old Hall, most of the stone used to build the college came from Ramsey Abbey near Ramsey, Cambridgeshire. Gonville and Caius has the oldest college chapel in either Oxford or Cambridge which has been in use as such
10.
World War I
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World War I, also known as the First World War, the Great War, or the War to End All Wars, was a global war originating in Europe that lasted from 28 July 1914 to 11 November 1918. More than 70 million military personnel, including 60 million Europeans, were mobilised in one of the largest wars in history and it was one of the deadliest conflicts in history, and paved the way for major political changes, including revolutions in many of the nations involved. The war drew in all the worlds great powers, assembled in two opposing alliances, the Allies versus the Central Powers of Germany and Austria-Hungary. These alliances were reorganised and expanded as more nations entered the war, Italy, Japan, the trigger for the war was the assassination of Archduke Franz Ferdinand of Austria, heir to the throne of Austria-Hungary, by Yugoslav nationalist Gavrilo Princip in Sarajevo on 28 June 1914. This set off a crisis when Austria-Hungary delivered an ultimatum to the Kingdom of Serbia. Within weeks, the powers were at war and the conflict soon spread around the world. On 25 July Russia began mobilisation and on 28 July, the Austro-Hungarians declared war on Serbia, Germany presented an ultimatum to Russia to demobilise, and when this was refused, declared war on Russia on 1 August. Germany then invaded neutral Belgium and Luxembourg before moving towards France, after the German march on Paris was halted, what became known as the Western Front settled into a battle of attrition, with a trench line that changed little until 1917. On the Eastern Front, the Russian army was successful against the Austro-Hungarians, in November 1914, the Ottoman Empire joined the Central Powers, opening fronts in the Caucasus, Mesopotamia and the Sinai. In 1915, Italy joined the Allies and Bulgaria joined the Central Powers, Romania joined the Allies in 1916, after a stunning German offensive along the Western Front in the spring of 1918, the Allies rallied and drove back the Germans in a series of successful offensives. By the end of the war or soon after, the German Empire, Russian Empire, Austro-Hungarian Empire, national borders were redrawn, with several independent nations restored or created, and Germanys colonies were parceled out among the victors. During the Paris Peace Conference of 1919, the Big Four imposed their terms in a series of treaties, the League of Nations was formed with the aim of preventing any repetition of such a conflict. This effort failed, and economic depression, renewed nationalism, weakened successor states, and feelings of humiliation eventually contributed to World War II. From the time of its start until the approach of World War II, at the time, it was also sometimes called the war to end war or the war to end all wars due to its then-unparalleled scale and devastation. In Canada, Macleans magazine in October 1914 wrote, Some wars name themselves, during the interwar period, the war was most often called the World War and the Great War in English-speaking countries. Will become the first world war in the sense of the word. These began in 1815, with the Holy Alliance between Prussia, Russia, and Austria, when Germany was united in 1871, Prussia became part of the new German nation. Soon after, in October 1873, German Chancellor Otto von Bismarck negotiated the League of the Three Emperors between the monarchs of Austria-Hungary, Russia and Germany
11.
Royal Army Medical Corps
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The Royal Army Medical Corps is a specialist corps in the British Army which provides medical services to all Army personnel and their families, in war and in peace. Together with the Royal Army Veterinary Corps, the Royal Army Dental Corps and Queen Alexandras Royal Army Nursing Corps, because it is not a fighting arm, under the Geneva Conventions, members of the RAMC may only use their weapons for self-defence. Other ranks do not fix bayonets, neither do they prefix Surgeon in front of their rank as medical officers of the Royal Navy do. The RAMC, like every other British regiment, has its own distinctive unit insignia, dark blue beret, the default Army colour worn by units without distinctive coloured berets. There is also a small attachment to Special Forces, the Medical Support Unit who wear the beret of the SAS. Cap badge depicting the Rod of Asclepius, surmounted by a crown, enclosed within a wreath, with the regimental motto In Arduis Fidelis. The cap badge is worn 1 inch above the eye on the beret. The cap badge of the ranks must also be backed by an oval patch of dull cherry-red coloured cloth measuring 3.81 cm wide and 6.35 cm high sewn directly to the beret. Officers do not use the backing, but have a cloth cap badge instead. Silver regimental collar badges, a miniature of the cap badge, stable belt comprising equal horizontal bands of dull cherry, royal blue, and old gold, reflecting the old uniform worn in the 1900s, the gold depicting the royal in the title. Silver belt buckle with engraved regimental badge, Medical services in the British armed services go as far back as the formation of the Standing Regular Army after the Restoration of Charles II in 1660. This was the first time a career was provided for a Medical Officer, known as the Regimental Surgeon, both in peacetime and in war. The Army was formed entirely on a basis, and an MO with a Warrant Officer as his Assistant Surgeon was appointed to each regiment. The MO was also for the first time concerned in the health of his troops. This regimental basis of appointment for MOs continued until 1873, when an army medical service was set up. There was much unhappiness in the Army Medical Service in the following years, for medical officers did not actually have military rank but advantages corresponding to relative military rank. They had inferior pay in India, excessive amounts of Indian and colonial service and they did not have their own identity as did the Army Service Corps, whose officers did have military rank. A number of complaints were published, and the British Medical Journal campaigned loudly, for over two years after 27 July 1887 there were no recruits to the Army Medical Department
12.
Porton Down
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Porton Down is a United Kingdom government military science park. It is situated slightly northeast of Porton near Salisbury, in Wiltshire, to the northwest lies the MoD Boscombe Down airfield operated by QinetiQ. On maps, the surrounding the complex is identified as a Danger Area. It is home to the Defence Science and Technology Laboratory, known as Dstl, the Dstl site occupies 7,000 acres. The site is commonly confused with the nearby training facility. Porton Down was set up during the First World War to provide a scientific basis for the British use of chemical warfare. Work at Porton started in March 1916, at the time, only a few cottages and farm buildings were scattered on the downs at Porton and Idmiston. Porton Down originally opened in 1916 as the Royal Engineers Experimental Station, the laboratorys remit was to conduct research and development regarding chemical weapons agents such as chlorine, mustard gas, and phosgene by the British armed forces in the First World War. By 1918, the two huts had become a large hutted camp with 50 officers and 1,100 other ranks. Studies in the Great War mainly concerned the dissemination of chlorine and phosgene and, later, by May 1917, the focus for anti-gas defence and respirator development had moved from London to Porton Down. After the Armistice, Porton Down was reduced to a skeleton staff, in 1919, the War Office set up the Holland Committee to consider the future of chemical warfare and defence. By 1920, the Cabinet agreed to the Committees recommendation that work should continue at Porton Down, from that date a slow permanent building programme began, coupled with the gradual recruitment of civilian scientists. By 1922, there were 380 servicemen,23 scientific and technical civil servants, by 1925, the civilian staff had doubled. By 1926, the defence aspects of Air Raid Precautions for the civilian population was added to the Stations responsibilities. Britain had ratified the 1925 Geneva Protocol in 1930 with reservations, a second chemical research and production facility operated at Sutton Oak, St Helens, Merseyside from 1923 to 1954. During the Second World War, research concentrated on chemical weapons such as mustard, plus biological weapons, including anthrax. In 1942, tests of an anthrax bio-weapon developed at Porton Down were held at Gruinard Island, the Common Cold Unit was sometimes confused with the Microbiological Research Establishment at Porton Down, with which it occasionally collaborated but was not officially connected. The CCU was located at Harvard Hospital, Harnham Down, on the west side of Salisbury
13.
University of Cambridge
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The University of Cambridge is a collegiate public research university in Cambridge, England, often regarded as one of the most prestigious universities in the world. Founded in 1209 and given royal status by King Henry III in 1231, Cambridge is the second-oldest university in the English-speaking world. The university grew out of an association of scholars who left the University of Oxford after a dispute with the townspeople, the two ancient universities share many common features and are often referred to jointly as Oxbridge. Cambridge is formed from a variety of institutions which include 31 constituent colleges, Cambridge University Press, a department of the university, is the worlds oldest publishing house and the second-largest university press in the world. The university also operates eight cultural and scientific museums, including the Fitzwilliam Museum, Cambridges libraries hold a total of around 15 million books, eight million of which are in Cambridge University Library, a legal deposit library. In the year ended 31 July 2015, the university had an income of £1.64 billion. The central university and colleges have an endowment of around £5.89 billion. The university is linked with the development of the high-tech business cluster known as Silicon Fen. It is a member of associations and forms part of the golden triangle of leading English universities and Cambridge University Health Partners. As of 2017, Cambridge is ranked the fourth best university by three ranking tables and no other institution in the world ranks in the top 10 for as many subjects. Cambridge is consistently ranked as the top university in the United Kingdom, the university has educated many notable alumni, including eminent mathematicians, scientists, politicians, lawyers, philosophers, writers, actors, and foreign Heads of State. Ninety-five Nobel laureates, fifteen British prime ministers and ten Fields medalists have been affiliated with Cambridge as students, faculty, by the late 12th century, the Cambridge region already had a scholarly and ecclesiastical reputation, due to monks from the nearby bishopric church of Ely. The University of Oxford went into suspension in protest, and most scholars moved to such as Paris, Reading. After the University of Oxford reformed several years later, enough remained in Cambridge to form the nucleus of the new university. A bull in 1233 from Pope Gregory IX gave graduates from Cambridge the right to teach everywhere in Christendom, the colleges at the University of Cambridge were originally an incidental feature of the system. No college is as old as the university itself, the colleges were endowed fellowships of scholars. There were also institutions without endowments, called hostels, the hostels were gradually absorbed by the colleges over the centuries, but they have left some indicators of their time, such as the name of Garret Hostel Lane. Hugh Balsham, Bishop of Ely, founded Peterhouse, Cambridges first college, the most recently established college is Robinson, built in the late 1970s
14.
University of Oxford
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The University of Oxford is a collegiate research university located in Oxford, England. It grew rapidly from 1167 when Henry II banned English students from attending the University of Paris, after disputes between students and Oxford townsfolk in 1209, some academics fled north-east to Cambridge where they established what became the University of Cambridge. The two ancient universities are frequently referred to as Oxbridge. The university is made up of a variety of institutions, including 38 constituent colleges, All the colleges are self-governing institutions within the university, each controlling its own membership and with its own internal structure and activities. Being a city university, it not have a main campus, instead, its buildings. Oxford is the home of the Rhodes Scholarship, one of the worlds oldest and most prestigious scholarships, the university operates the worlds oldest university museum, as well as the largest university press in the world and the largest academic library system in Britain. Oxford has educated many notable alumni, including 28 Nobel laureates,27 Prime Ministers of the United Kingdom, the University of Oxford has no known foundation date. Teaching at Oxford existed in form as early as 1096. It grew quickly in 1167 when English students returned from the University of Paris, the historian Gerald of Wales lectured to such scholars in 1188 and the first known foreign scholar, Emo of Friesland, arrived in 1190. The head of the university had the title of chancellor from at least 1201, the university was granted a royal charter in 1248 during the reign of King Henry III. After disputes between students and Oxford townsfolk in 1209, some academics fled from the violence to Cambridge, the students associated together on the basis of geographical origins, into two nations, representing the North and the South. In later centuries, geographical origins continued to many students affiliations when membership of a college or hall became customary in Oxford. At about the time, private benefactors established colleges as self-contained scholarly communities. Among the earliest such founders were William of Durham, who in 1249 endowed University College, thereafter, an increasing number of students lived in colleges rather than in halls and religious houses. In 1333–34, an attempt by some dissatisfied Oxford scholars to found a new university at Stamford, Lincolnshire was blocked by the universities of Oxford and Cambridge petitioning King Edward III. Thereafter, until the 1820s, no new universities were allowed to be founded in England, even in London, thus, Oxford and Cambridge had a duopoly, the new learning of the Renaissance greatly influenced Oxford from the late 15th century onwards. Among university scholars of the period were William Grocyn, who contributed to the revival of Greek language studies, and John Colet, the noted biblical scholar. With the English Reformation and the breaking of communion with the Roman Catholic Church, recusant scholars from Oxford fled to continental Europe, as a centre of learning and scholarship, Oxfords reputation declined in the Age of Enlightenment, enrolments fell and teaching was neglected
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World War II
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World War II, also known as the Second World War, was a global war that lasted from 1939 to 1945, although related conflicts began earlier. It involved the vast majority of the worlds countries—including all of the great powers—eventually forming two opposing alliances, the Allies and the Axis. It was the most widespread war in history, and directly involved more than 100 million people from over 30 countries. Marked by mass deaths of civilians, including the Holocaust and the bombing of industrial and population centres. These made World War II the deadliest conflict in human history, from late 1939 to early 1941, in a series of campaigns and treaties, Germany conquered or controlled much of continental Europe, and formed the Axis alliance with Italy and Japan. Under the Molotov–Ribbentrop Pact of August 1939, Germany and the Soviet Union partitioned and annexed territories of their European neighbours, Poland, Finland, Romania and the Baltic states. In December 1941, Japan attacked the United States and European colonies in the Pacific Ocean, and quickly conquered much of the Western Pacific. The Axis advance halted in 1942 when Japan lost the critical Battle of Midway, near Hawaii, in 1944, the Western Allies invaded German-occupied France, while the Soviet Union regained all of its territorial losses and invaded Germany and its allies. During 1944 and 1945 the Japanese suffered major reverses in mainland Asia in South Central China and Burma, while the Allies crippled the Japanese Navy, thus ended the war in Asia, cementing the total victory of the Allies. World War II altered the political alignment and social structure of the world, the United Nations was established to foster international co-operation and prevent future conflicts. The victorious great powers—the United States, the Soviet Union, China, the United Kingdom, the Soviet Union and the United States emerged as rival superpowers, setting the stage for the Cold War, which lasted for the next 46 years. Meanwhile, the influence of European great powers waned, while the decolonisation of Asia, most countries whose industries had been damaged moved towards economic recovery. Political integration, especially in Europe, emerged as an effort to end pre-war enmities, the start of the war in Europe is generally held to be 1 September 1939, beginning with the German invasion of Poland, Britain and France declared war on Germany two days later. The dates for the beginning of war in the Pacific include the start of the Second Sino-Japanese War on 7 July 1937, or even the Japanese invasion of Manchuria on 19 September 1931. Others follow the British historian A. J. P. Taylor, who held that the Sino-Japanese War and war in Europe and its colonies occurred simultaneously and this article uses the conventional dating. Other starting dates sometimes used for World War II include the Italian invasion of Abyssinia on 3 October 1935. The British historian Antony Beevor views the beginning of World War II as the Battles of Khalkhin Gol fought between Japan and the forces of Mongolia and the Soviet Union from May to September 1939, the exact date of the wars end is also not universally agreed upon. It was generally accepted at the time that the war ended with the armistice of 14 August 1945, rather than the formal surrender of Japan
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Pyruvate
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Pyruvic acid is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the base, CH3COCOO−, is a key intermediate in several metabolic pathways. Pyruvic acid can be made from glucose through glycolysis, converted back to carbohydrates via gluconeogenesis and it can also be used to construct the amino acid alanine and can be converted into ethanol or lactic acid via fermentation. Pyruvic acid supplies energy to cells through the citric acid cycle when oxygen is present, pyruvic acid is a colorless liquid with a smell similar to that of acetic acid and is miscible with water. It is the output of the metabolism of known as glycolysis. One molecule of glucose breaks down into two molecules of pyruvate, which are used to provide further energy, in one of two ways. Pyruvate is converted into acetyl-coenzyme A, which is the input for a series of reactions known as the Krebs cycle. Pyruvate is also converted to oxaloacetate by an reaction, which replenishes Krebs cycle intermediates, also. These reactions are named after Hans Adolf Krebs, the biochemist awarded the 1953 Nobel Prize for physiology, jointly with Fritz Lipmann, for research into metabolic processes. The cycle is known as the citric acid cycle or tricarboxylic acid cycle. If insufficient oxygen is available, the acid is broken down anaerobically, creating lactate in animals and ethanol in plants, Pyruvate is a key intersection in the network of metabolic pathways. Pyruvate can be converted into carbohydrates via gluconeogenesis, to fatty acids or energy through acetyl-CoA, to the amino acid alanine, therefore, it unites several key metabolic processes. In glycolysis, phosphoenolpyruvate is converted to pyruvate by pyruvate kinase and this reaction is strongly exergonic and irreversible, in gluconeogenesis, it takes two enzymes, pyruvate carboxylase and PEP carboxykinase, to catalyze the reverse transformation of pyruvate to PEP. Compound C00074 at KEGG Pathway Database, enzyme 2.7.1.40 at KEGG Pathway Database. Compound C00022 at KEGG Pathway Database, click on genes, proteins and metabolites below to link to respective articles. Pyruvate decarboxylation by the pyruvate dehydrogenase complex produces acetyl-CoA, carboxylation by pyruvate carboxylase produces oxaloacetate. Transamination by alanine transaminase produces alanine, reduction by lactate dehydrogenase produces lactate. Pyruvate is sold as a supplement, though evidence supporting this use is lacking
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Fluoroacetic acid
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Fluoroacetic acid is a chemical compound with formula CH2FCOOH. The sodium salt, sodium fluoroacetate, is used as a pesticide and it inhibits the aconitase step of the citric acid cycle. Fluoroacetate occurs naturally in at least 40 plants in Australia, Brazil and it was first identified in Dichapetalum cymosum, commonly known as gifblaar or poison leaf, by Marais in 1944. As early as 1904, colonists in Sierra Leone used extracts of Chailletia toxicaria, several native Australian plant genera contain the toxin, including, Gastrolobium, Gompholobium, Oxylobium, Nemcia, and Acacia. Gastrolobium is a genus of flowering plants in the family Fabaceae, there are over 100 species in this genus, and all but two are native to the south west region of Western Australia, where they are known as poison peas. Gastrolobium growing in south western Australia are unique in their ability to concentrate fluoroacetate from low-fluorine soils, similarly, after bushfires in north-western Queensland, cattlemen have to move livestock before the poisonous Gastrolobium grandiflorum emerges from the ashes
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Fluorocitric acid
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Fluorocitric acid is a fluorinated carboxylic acid derived from citric acid by substitution of one hydrogen by a fluorine atom. The appropriate anion is called fluorocitrate and it is a metabolite of fluoroacetic acid and is very toxic because it is not processable using aconitase in the citrate cycle. The enzyme is inhibited and the cycle stops working, citric acid Fluoroacetic acid Citrate cycle PubChem, Fluorocitrate Human Metabolome Database, Fluorocitric acid The Chemical and Biochemical Properties of Fluorocitric Acid Pdf
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Croonian Lecture
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The Croonian Lectures are prestigious lectureships given at the invitation of the Royal Society and the Royal College of Physicians. Among the papers of William Croone at his death in 1684, was a plan to endow one lectureship at both the Royal Society and the Royal College of Physicians. One lecture was to be delivered by a Fellow to the Royal College of Physicians, the Royal Society lecture series began in 1738 and that of the Royal College of Physicians in 1749. Croone became an original Fellow of the Royal Society in May 1663 and he also became one of the original Fellows of the College of Physicians on 29 July 1675. He was appointed lecturer on anatomy at Surgeons hall in 1670 and pursued research in several important subjects of his day, including respiration, muscular motion, and generation. 2007 Peter J. Goadsby, Bench to bedside, headache 20072006 Peter John Ratcliffe, Understanding hypoxia signalling in cells, a new therapeutic opportunity
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Babraham Institute
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The Babraham Institute, is an independent charitable life sciences institute involved in biomedical research, set in an extensive parkland estate just south of Cambridge. Its current director is Prof. Michael Wakelam, the institute is located on the Babraham Hall estate, situated six miles south-east of Cambridge by the Gog Magog Downs, close to where the Via Devana, crossed the prehistoric Icknield Way. The estate includes Babraham Hall, designed in the Jacobean style by Philip Hardwick, in 1993, Roslin and Babraham formed two separate institutes, at which time the Babraham Institute assumed its current name. In 1994, The AFRC was disbanded and The Biotechnology and Biological Sciences Research Council was formed, all work with direct relevance to agriculture ceased in 1998. The institute has the status of a department within the University of Cambridge. The research laboratories of the institute are grouped into four programmes, Signalling and these proteins make up the signalling pathways that organise how cells and organs develop and react to their environment. Lymphocyte Signalling and Development, investigates signal transduction pathways that regulate the survival, nuclear Dynamics, carries out basic research to create an integrated understanding of control of genome function by its structure and dynamic. The four institute Programmes are funded by four Institute Strategic Programme Grants awarded by the Biotechnology, additional grant funding comes from the BBSRC, MRC, Wellcome Trust, other charities, European Commission and industry
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Elizabeth II
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Elizabeth II has been Queen of the United Kingdom, Canada, Australia, and New Zealand since 6 February 1952. Elizabeth was born in London as the eldest child of the Duke and Duchess of York, later King George VI and Queen Elizabeth and her father acceded to the throne on the abdication of his brother Edward VIII in 1936, from which time she was the heir presumptive. She began to undertake duties during the Second World War. Elizabeths many historic visits and meetings include a visit to the Republic of Ireland. She has seen major changes, such as devolution in the United Kingdom, Canadian patriation. She has reigned through various wars and conflicts involving many of her realms and she is the worlds oldest reigning monarch as well as Britains longest-lived. In October 2016, she became the longest currently reigning monarch, in 2017 she became the first British monarch to commemorate a Sapphire Jubilee. Elizabeth has occasionally faced republican sentiments and press criticism of the family, however, support for the monarchy remains high. Elizabeth was born at 02,40 on 21 April 1926, during the reign of her paternal grandfather and her father, Prince Albert, Duke of York, was the second son of the King. Her mother, Elizabeth, Duchess of York, was the youngest daughter of Scottish aristocrat Claude Bowes-Lyon, 14th Earl of Strathmore and she was delivered by Caesarean section at her maternal grandfathers London house,17 Bruton Street, Mayfair. Elizabeths only sibling, Princess Margaret, was born in 1930, the two princesses were educated at home under the supervision of their mother and their governess, Marion Crawford, who was casually known as Crawfie. Lessons concentrated on history, language, literature and music, Crawford published a biography of Elizabeth and Margarets childhood years entitled The Little Princesses in 1950, much to the dismay of the royal family. The book describes Elizabeths love of horses and dogs, her orderliness, others echoed such observations, Winston Churchill described Elizabeth when she was two as a character. She has an air of authority and reflectiveness astonishing in an infant and her cousin Margaret Rhodes described her as a jolly little girl, but fundamentally sensible and well-behaved. During her grandfathers reign, Elizabeth was third in the line of succession to the throne, behind her uncle Edward, Prince of Wales, and her father, the Duke of York. Although her birth generated public interest, she was not expected to become queen, many people believed that he would marry and have children of his own. When her grandfather died in 1936 and her uncle succeeded as Edward VIII, she became second-in-line to the throne, later that year, Edward abdicated, after his proposed marriage to divorced socialite Wallis Simpson provoked a constitutional crisis. Consequently, Elizabeths father became king, and she became heir presumptive, if her parents had had a later son, she would have lost her position as first-in-line, as her brother would have been heir apparent and above her in the line of succession
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Royal Society of Edinburgh
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The Royal Society of Edinburgh is Scotlands national academy of science and letters. It is a charity, operating on a wholly independent and non-party-political basis. As of 2014 it has more than 1,500 Fellows, the Society covers a broader selection of fields than the Royal Society of London including literature and history. Fellowship includes people from a range of disciplines – science & technology, arts, humanities, medicine, social science, business. The Medals were instituted in 2000 by Queen Elizabeth II, whose permission is required to make a presentation, past winners include, The Lord Kelvin Medal is the Senior Prize for Physical, Engineering and Informatics Sciences. It is awarded annually to a person who has achieved distinction nationally and internationally, winners receive a silver medal and are required to deliver a public lecture in Scotland. The award is named after William Thomson, 1st Baron Kelvin, who was a mathematical physicist and engineer. Senior Prize-winners are required to have a Scottish connection but can be based anywhere in the world, the Keith medal has been historically awarded every four years for a scientific paper published in the societys scientific journals, preference being given to a paper containing a discovery. It is awarded alternately for papers on Mathematics or Earth and Environmental Sciences, the medal was founded in 1827 as a result of a bequest by Alexander Keith of Dunottar, the first Treasurer of the Society. The prize was founded in 1855 by Sir Thomas Makdougall Brisbane, the cumbersome name was changed the following year to the Edinburgh Philosophical Society. Under the leadership of Prof. Thus, for the first four decades of the 19th century, by the 1850s, the society once again unified its membership under one journal. During the 19th century the society produced many scientists whose ideas laid the foundation of the modern sciences, from the 20th century onward, the society functioned not only as a focal point for Scotlands eminent scientists, but also the arts and humanities. It still exists today and continues to promote research in Scotland. In February 2014, Dame Jocelyn Bell Burnell was announced as the societys first female president, taking up her position in October
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Alexander Ogston
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Sir Alexander Ogston KCVO FRS CM MD was a Scottish surgeon, famous for his discovery of Staphylococcus. He was the eldest son of Prof. Francis Ogston, Professor of Medical Jurisprudence at the University of Aberdeen, Ogston began his medical training at Marischal College in 1862 and graduated in 1865 with honours in medicine and surgery at the age of 21. He obtained his MD a year later in 1866 and he was appointed as a full surgeon to the Aberdeen Royal Infirmary in 1874. He was Assistant Professor of Medical Jurisprudence and Materia Medica, Lecturer in Ophthalmology and he is credited with the introduction of carbolic spray to Aberdeen. Ogston was reported to have called on Joseph Lister and rigorously followed his antiseptic principals and these are aptly phrased in a small ditty composed by his students. The spray, the spray, the antiseptic spray A. O. would shower it morning, night and day For every sort of scratch Where others would attach A sticking plaster patch He gave the spray. Ogston followed the work of contemporaries such as Koch, J. C. Ewart from Edinburgh. Following his examination of the organisms from the abscess of James Davidson, Ogston used the shed behind his house as a laboratory to continue his research, following Kochs postulates and staining methods, Ogston set about isolating the causative organism of Davidsons wound. By experiment Ogston concluded that the conditions for cultivation of this organism were hens egg medium grown in small bottles shielded from contamination by glass shades. Using samples from 82 abscesses, Ogston successfully isolated bacteria from 65 samples and he was then able to transfer pure colonies to guinea-pigs, white mice or wild mice. He also noted that a transferring a 1/146016000 dilution of the original pus sample could induce abscesses in new subjects, Ogston demonstrated that these bacteria could be killed by heat or carbolic acid, fulfilling Kochs postulates. He also noted that micrococci so deleterious when injected were seemingly harmless on the surface of wounds, an observation of the existence of some staphylococci as part of the normal flora. Ogston encountered a great deal of difficulty convincing the establishment of his observations on Staphylococcus. The Aberdeen branch of the BMA, received his findings with disbelief, the editor of the British Medical Journal stated at the time can anything good come out of Aberdeen. After a careful study of the evidence presented by Ogston, his contemporary, Joseph Lister agreed with his findings however, another peer, Watson Cheyne was still sceptical. Given this local skeptisim, Ogston decided to present his discoveries to a congress in Berlin where he had previously presented a paper genu valgum on 9 April 1880. Ogston delivered this presentation on absesses in German which was then published and he was subsequently made a Fellow of the German Surgical Society despite his youth. The next year Ogston published his observations in the British Medical Journal, after this point his papers were refused and instead he published in the Journal of Anatomy and Physiology
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JSTOR
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JSTOR is a digital library founded in 1995. Originally containing digitized back issues of journals, it now also includes books and primary sources. It provides full-text searches of almost 2,000 journals, more than 8,000 institutions in more than 160 countries have access to JSTOR, most access is by subscription, but some older public domain content is freely available to anyone. William G. Bowen, president of Princeton University from 1972 to 1988, JSTOR originally was conceived as a solution to one of the problems faced by libraries, especially research and university libraries, due to the increasing number of academic journals in existence. Most libraries found it prohibitively expensive in terms of cost and space to maintain a collection of journals. By digitizing many journal titles, JSTOR allowed libraries to outsource the storage of journals with the confidence that they would remain available long-term, online access and full-text search ability improved access dramatically. Bowen initially considered using CD-ROMs for distribution, JSTOR was initiated in 1995 at seven different library sites, and originally encompassed ten economics and history journals. JSTOR access improved based on feedback from its sites. Special software was put in place to make pictures and graphs clear, with the success of this limited project, Bowen and Kevin Guthrie, then-president of JSTOR, wanted to expand the number of participating journals. They met with representatives of the Royal Society of London and an agreement was made to digitize the Philosophical Transactions of the Royal Society dating from its beginning in 1665, the work of adding these volumes to JSTOR was completed by December 2000. The Andrew W. Mellon Foundation funded JSTOR initially, until January 2009 JSTOR operated as an independent, self-sustaining nonprofit organization with offices in New York City and in Ann Arbor, Michigan. JSTOR content is provided by more than 900 publishers, the database contains more than 1,900 journal titles, in more than 50 disciplines. Each object is identified by an integer value, starting at 1. In addition to the site, the JSTOR labs group operates an open service that allows access to the contents of the archives for the purposes of corpus analysis at its Data for Research service. This site offers a facility with graphical indication of the article coverage. Users may create focused sets of articles and then request a dataset containing word and n-gram frequencies and they are notified when the dataset is ready and may download it in either XML or CSV formats. The service does not offer full-text, although academics may request that from JSTOR, JSTOR Plant Science is available in addition to the main site. The materials on JSTOR Plant Science are contributed through the Global Plants Initiative and are only to JSTOR
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International Standard Book Number
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The International Standard Book Number is a unique numeric commercial book identifier. An ISBN is assigned to each edition and variation of a book, for example, an e-book, a paperback and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, the method of assigning an ISBN is nation-based and varies from country to country, often depending on how large the publishing industry is within a country. The initial ISBN configuration of recognition was generated in 1967 based upon the 9-digit Standard Book Numbering created in 1966, the 10-digit ISBN format was developed by the International Organization for Standardization and was published in 1970 as international standard ISO2108. Occasionally, a book may appear without a printed ISBN if it is printed privately or the author does not follow the usual ISBN procedure, however, this can be rectified later. Another identifier, the International Standard Serial Number, identifies periodical publications such as magazines, the ISBN configuration of recognition was generated in 1967 in the United Kingdom by David Whitaker and in 1968 in the US by Emery Koltay. The 10-digit ISBN format was developed by the International Organization for Standardization and was published in 1970 as international standard ISO2108, the United Kingdom continued to use the 9-digit SBN code until 1974. The ISO on-line facility only refers back to 1978, an SBN may be converted to an ISBN by prefixing the digit 0. For example, the edition of Mr. J. G. Reeder Returns, published by Hodder in 1965, has SBN340013818 -340 indicating the publisher,01381 their serial number. This can be converted to ISBN 0-340-01381-8, the check digit does not need to be re-calculated, since 1 January 2007, ISBNs have contained 13 digits, a format that is compatible with Bookland European Article Number EAN-13s. An ISBN is assigned to each edition and variation of a book, for example, an ebook, a paperback, and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, a 13-digit ISBN can be separated into its parts, and when this is done it is customary to separate the parts with hyphens or spaces. Separating the parts of a 10-digit ISBN is also done with either hyphens or spaces, figuring out how to correctly separate a given ISBN number is complicated, because most of the parts do not use a fixed number of digits. ISBN issuance is country-specific, in that ISBNs are issued by the ISBN registration agency that is responsible for country or territory regardless of the publication language. Some ISBN registration agencies are based in national libraries or within ministries of culture, in other cases, the ISBN registration service is provided by organisations such as bibliographic data providers that are not government funded. In Canada, ISBNs are issued at no cost with the purpose of encouraging Canadian culture. In the United Kingdom, United States, and some countries, where the service is provided by non-government-funded organisations. Australia, ISBNs are issued by the library services agency Thorpe-Bowker
