The Ruisi cathedral of the Mother of God is a Georgian Orthodox church in the village of Ruisi in Georgia's east-central Shida Kartli region. Originally built in the 8th–9th century, the church was remodeled in the 11th century and rebuilt in the 15th century. It is a cross-in-square church with a tall dome and a horseshoe apse on the east. The cathedral is inscribed on the list of Georgia's Immovable Cultural Monuments of National Significance.

The Immovable Cultural Monuments of National Significance are buildings, structures, sites, or places in Georgia that have been determined to have nationwide cultural significance by meeting special criteria developed by the Ministry of Culture and are subject to preservation by the state.