Rupali Ganguly is an Indian actress who primarily works in Hindi television. Ganguly is widely recognised for her portrayal of Manisha "Monisha" Singh Sarabhai in the cult sitcom Sarabhai vs Sarabhai (2004–2006) and Anupamaa in the drama Anupamaa (2020–present). She is a recipient of two Indian Telly Awards and one Indian Television Academy Award.

Sarabhai vs Sarabhai is an Indian Hindi-language television sitcom that aired on STAR One from 1 November 2004 to 16 April 2006 and on Disney+ Hotstar from 15 May to 17 July 2017 for two seasons in 80 episodes altogether. The show was directed by Deven Bhojani and produced by Jamnadas D. Majethia and Aatish Kapadia under the production banner of Hats Off Productions. Starring an ensemble cast of Satish Shah, Ratna Pathak Shah, Sumeet Raghavan, Rupali Ganguly and Rajesh Kumar, the show revolves around the Sarabhais, a quintessential upper-class Gujarati family living in the upmarket neighbourhood of Cuffe Parade in South Mumbai. The family members include the matriarch, Maya; her husband, Indravadan; their two sons, Sahil and Rosesh; Sahil's wife, Monisha; Indravadan and Maya's son-in-law, Dushyant; and Indravadan's brother-in-law, Madhusudan Fufa. Regarded as being ahead of its generation in terms of its concept, writing, and average viewership ratings at the time of its initial release, the show has gone on to become a cult classic.