The Russo-Persian Wars or Russo-Iranian Wars were a series of conflicts between 1651 and 1828, concerning Persia and the Russian Empire. Russia and Persia fought these wars over disputed governance of territories and countries in the Caucasus. The main territories disputed were Aran, Georgia and Armenia, as well as much of Dagestan – generally referred to as Transcaucasia – and considered part of the Safavid Iran prior to the Russo-Persian Wars. Over the course of the five Russo-Persian Wars, the governance of these regions transferred between the two empires. Between the Second and Third Russo-Persian Wars, there was an interbellum period in which a number of treaties were drawn up between the Russian and the Persian Empires, as well as between both parties and the Ottoman Empire. Ottoman interest in these territories further complicated the wars, with both sides forming alliances with the Ottoman Empire at different points throughout the wars. Following the Treaty of Turkmenchay, which concluded the Fifth Russo-Persian War, Persia ceded much of its Transcaucasian territory to the Russian Empire.

Karabakh is a geographic region in present-day southwestern Azerbaijan and eastern Armenia, extending from the highlands of the Lesser Caucasus down to the lowlands between the rivers Kura and Aras. It is divided into three regions: Highland Karabakh, Lowland Karabakh, and the eastern slopes of the Zangezur Mountains.