Ryuzo Yanagimachi was a Japanese-born, American-based scientist. He made numerous key contributions to the study of mammalian fertilization, and he was also a pioneer in the cloning field. Accordingly, he assisted in fertilization technologies such as in vitro fertilization and direct sperm injection into the egg, which are widely used today in human infertility clinics throughout the world. In 1997, his laboratory at the University of Hawaiʻi at Mānoa successfully cloned mice using the Honolulu technique.

The University of Hawaiʻi at Mānoa is a public land-grant research university in Mānoa, a neighborhood of Honolulu, Hawaii. It is the flagship campus of the University of Hawaiʻi system and houses the main offices of the system. Most of the campus occupies the eastern half of the mouth of Mānoa Valley, with the John A. Burns School of Medicine located adjacent to the Kakaʻako Waterfront Park.