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SECIS element
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In biology, the SECIS element is an RNA element around 60 nucleotides in length that adopts a stem-loop structure. This structural motif directs the cell to translate UGA codons as selenocysteines. SE
Predicted secondary structure and sequence conservation of SECIS_1. Letters correspond to the IUPAC notation system for nucleotides.
Predicted secondary structure and sequence conservation of SECIS_1. Letters correspond to the IUPAC notation system for nucleotides.
Five prime untranslated region
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The five prime untranslated region, or leader sequence, transcript leader, or leader RNA, is the region of a messenger RNA that is directly upstream from the initiation codon. This region is important
SECIS element
…an mRNA, and can cause multiple UGA codons within the mRNA to code for selenocysteine. One archaeal SECIS element, in Methanococcus, is located in the 5' UTR. In any case, it serves to recruit EEFSEC or SelB, the specialized homolog of EF-Tu/eEF1&alpha, with the ability to read tRNASec. The SECIS elements…
The binding of an IRP (iron regulatory protein) to and IRE (iron response element), which are hairpin loops, regulate translation.
The binding of an IRP (iron regulatory protein) to and IRE (iron response element), which are hairpin loops, regulate translation.