City of Brussels was a British passenger liner that set the record for the fastest Atlantic eastbound voyage in 1869, becoming the first record breaker driven by a screw. Built by Tod and Macgregor, she served the Inman Line until 1883 when she sank with the loss of ten people after a collision while entering the Mersey.

The Inman Line was one of the three largest 19th-century British passenger shipping companies on the North Atlantic, along with the White Star Line and Cunard Line. Founded in 1850, it was absorbed in 1893 into American Line. The firm's formal name for much of its history was the Liverpool, Philadelphia and New York Steamship Company, but it was also variously known as the Liverpool and Philadelphia Steamship Company, as Inman Steamship Company, Limited, and, in the last few years before absorption, as the Inman and International Steamship Company.