Sacred Heart Cathedral, located in Davenport, Iowa, United States, is a Catholic cathedral and a parish church in the Diocese of Davenport. The cathedral is located on a bluff overlooking the Mississippi River to the east of Downtown Davenport. It is listed on the National Register of Historic Places as part of the Sacred Heart Roman Catholic Cathedral Complex. This designation includes the church building, rectory, and the former convent, which was torn down in 2012. The cathedral is adjacent to the Cork Hill Historic District, also on the National Register. Its location on Cork Hill, a section of the city settled by Irish immigrants.

The Diocese of Davenport is a Latin Church ecclesiastical jurisdiction, or diocese, of the Catholic Church for the southeastern quarter of the state of Iowa in the United States.