Sadiola is a commune and small town in western Mali, south of Kayes. The commune includes 46 villages and in 2009 had a population of 39,305.

Kayes Region is one of ten first level national subdivisions in Mali called Regions. It is the first administrative area of Mali and covers an area of 120,760 square kilometres or 46,630 square miles. Its capital is the town of Kayes. The province was historically part of the Ghana Empire and the Mali Empire.