Safety Harbor is a city on the west shore of Tampa Bay in Pinellas County, Florida, United States. It was settled in 1823 and incorporated in 1917. The population was 17,072 at the 2020 census.

Tampa Bay is a large natural harbor and shallow estuary connected to the Gulf of Mexico on the west-central coast of Florida, comprising Hillsborough Bay, McKay Bay, Old Tampa Bay, Middle Tampa Bay, and Lower Tampa Bay. The largest freshwater inflow into the bay is the Hillsborough River, which flows into Hillsborough Bay in downtown Tampa. Many other smaller rivers and streams also flow into Tampa Bay, resulting in a large watershed area.