The Sagami Line is a railway line in Kanagawa Prefecture, Japan, operated by East Japan Railway Company. It approximately parallels the east bank of the Sagami River. The line connects Hashimoto Station in Sagamihara and Chigasaki Station in Chigasaki.

Kanagawa Prefecture is a prefecture of Japan located in the Kantō region of Honshu. Kanagawa Prefecture is the second-most populous prefecture of Japan at 9,221,129 and third-densest at 3,800 inhabitants per square kilometre (9,800/sq mi). Its geographic area of 2,415 km2 (932 sq mi) makes it fifth-smallest. Kanagawa Prefecture borders Tokyo to the north, Yamanashi Prefecture to the northwest and Shizuoka Prefecture to the west.