The Sagamore Bridge in Sagamore, Massachusetts carries Route 6 and the Claire Saltonstall Bikeway across the Cape Cod Canal, connecting Cape Cod with the mainland of Massachusetts. It is the more northeastern of two automobile canal crossings, the other being the Bourne Bridge. Most traffic approaching from the north follows Massachusetts Route 3 which ends at Route 6 just north of the bridge, and the bridge provides direct expressway connections from Boston and Interstate 93.

U.S. Route 6 (US 6) in Massachusetts is a 117.952-mile-long (189.825 km) portion of the cross-country route connecting Providence, Rhode Island, to Fall River, New Bedford, and Cape Cod. In the Fall River and New Bedford areas, US 6 parallels Interstate 195 (I-195). On Cape Cod, US 6 is a highway interconnecting the towns of the area. The freeway section in this area is also known as the Mid-Cape Highway. The highway is also alternatively signed as the "Grand Army of the Republic Highway".