Senator Datuk Seri Saifuddin Nasution bin Ismail is a Malaysian politician who has served as the Minister of Home Affairs in Unity Government administration under Prime Minister Anwar Ibrahim and Senator since December 2022. He served as the Minister of Domestic Trade and Consumer Affairs in the PH administration under former Prime Minister Mahathir Mohamad from July 2018 to the collapse of the PH administration in February 2020, Member of Parliament (MP) for Kulim-Bandar Baharu from May 2018 to November 2022 and for Machang from March 2008 to May 2013 as well as Member of the Penang State Legislative Assembly (MLA) for Pantai Jerejak from May 2018 to August 2023 and MLA of Kedah for Lunas from November 2000 to March 2004. He is a member of the People's Justice Party (PKR), a component party of the PH coalition. He has also served as the Secretary-General of PKR from January 2010 to his resignation in October 2014 and again since November 2016 as well as the Secretary-General of PH since March 2020.

The current position for Malaysian Minister of Home Affairs is hold by Saifuddin Nasution Ismail since 3 December 2022. The minister is supported by the Deputy Ministers of Home Affairs. The Minister administers the portfolio through the Ministry of Home Affairs.