Saint-Georges is a commune of French Guiana, an overseas region and department of France located in South America. It lies on the Oyapock River, opposite the Brazilian town of Oiapoque. The town contains a town hall, a French Foreign Legion detachment, and some hotels. Saint-Georges has been one of the three sub-prefectures of French Guiana and the seat of the Arrondissement of Saint-Georges since October 2022.

The Oyapock or Oiapoque is a 403-kilometre (250 mi) long river in South America that forms most of the border between the French overseas department of French Guiana and the Brazilian state of Amapá.