Saint-Nicolas-de-Bourgueil is a French wine Appellation d'origine contrôlée (AOC) in the Loire valley on the right bank of the river Loire. The AOC was created by a decree on July 31, 1937, covering about 800 hectares in the commune of Saint-Nicolas-de-Bourgueil in the département of Indre-et-Loire.

The Loire Valley wine region includes the French wine regions situated along the river Loire from the Muscadet region near the city of Nantes on the Atlantic coast to the region of Sancerre and Pouilly-Fumé just southeast of the city of Orléans in north central France. In between are the regions of Anjou wine, Saumur, Bourgueil, Chinon, and Vouvray. The Loire Valley itself follows the river through the Loire department to the river's origins in the Cévennes but the majority of the wine production takes place in the regions noted above. The area includes 87 appellations under the Appellation d'origine contrôlée (AOC) and Indication Géographique Protégée (IGP) systems. While the majority of production is white wine from the Chenin blanc, Sauvignon blanc and Melon de Bourgogne grapes, there are red wines made from Cabernet franc. In addition to still wines, rosé, sparkling and dessert wines are also produced. With Crémant production throughout the Loire, it is the second largest sparkling wine producer in France after Champagne. Among these different wine styles, Loire wines tend to exhibit characteristic fruitiness with fresh, crisp flavors-especially in their youth. The Loire Valley has a long history of winemaking dating back to the 1st century. In the High Middle Ages, the wines of the Loire Valley were the most esteemed wines in England and France, even more prized than those from Bordeaux.