St. Helena Island is a Sea Island in Beaufort County, South Carolina, United States. The island is connected to Beaufort by U.S. Highway 21. The island has a land area of about 64 sq mi (170 km2) and a population of 8,763 as of the 2010 census. It is included as part of the Hilton Head Island-Beaufort Micropolitan Area. The island is renowned for its rural Lowcountry character and being a major center of African-American Gullah culture and language. It is considered to be the geographic influence behind the children's television program Gullah Gullah Island.

Beaufort County is a county in the U.S. state of South Carolina. As of the 2020 census, its population was 187,117. Its county seat is Beaufort and its largest community is Hilton Head Island.