"The Saint Louis Blues" is a popular American song composed by W. C. Handy in the blues style and published in September 1914. It was one of the first blues songs to succeed as a pop song and remains a fundamental part of jazz musicians' repertoire. Benny Goodman, Louis Armstrong, Cab Calloway, Bing Crosby, Bessie Smith, Eartha Kitt, Count Basie, Glenn Miller, Guy Lombardo, Peanuts Hucko, Art Tatum, and the Boston Pops Orchestra are among the artists who have recorded it. The song has been called "the jazzman's Hamlet". Composer William Grant Still arranged a version of the song in 1916 while working with Handy.

William Christopher Handy was an American composer and musician who referred to himself as the Father of the Blues. He was one of the most influential songwriters in the United States. One of many musicians who played the distinctively American blues music, Handy did not create the blues genre but was the one of the first to publish music in the blues form, thereby taking the blues from a regional music style with a limited audience to a new level of popularity.