The Saint Louis River is a river in the U.S. states of Minnesota and Wisconsin that flows into Lake Superior. The largest U.S. river to flow into the lake, it is 192 miles (309 km) in length and starts 13 miles (21 km) east of Hoyt Lakes, Minnesota. The river's watershed covers 3,634 square miles (9,410 km2). Near the Twin Ports of Duluth, Minnesota and Superior, Wisconsin, the river becomes a freshwater estuary.

Lake Superior is the largest freshwater lake in the world by surface area and the third-largest freshwater lake by volume, holding 10% of the world's surface fresh water. Located in central North America, it is the northernmost and westernmost of the Great Lakes of North America, straddling the Canada–United States border with the Canadian province of Ontario to the north and east and the U.S. states of Minnesota to the west and Michigan and Wisconsin to the south. It drains into Lake Huron via St. Marys River, then through the lower Great Lakes to the St. Lawrence River and ultimately the Atlantic Ocean.