Saint Louis School, located in the neighborhood of St. Louis Heights in Honolulu, Hawaii, is a historic Roman Catholic college preparatory school for boys. It was founded in 1846 to serve Catholics in the former Kingdom of Hawaii. Located within the Roman Catholic Diocese of Honolulu, it is affiliated with the Society of Mary, a religious order of brothers and priests called the Marianists who also administer Chaminade University of Honolulu, formerly the college section of Saint Louis School. It is located near Sacred Hearts Academy, a girls' school founded by the Congregation of the Sacred Hearts of Jesus and Mary, and both schools hold joint programs such as cultural festivals and the JROTC.

John Awena-ika-lani-keahi-o-ka-lua-o-Pele Carey Lane, was Mayor of Honolulu from 1915 to 1917.