Saitama University is a Japanese national university located in a suburban area of Sakura-ku, Saitama City, capital of Saitama Prefecture in Tokyo Metropolitan Area.

Sakura-ku is one of ten wards of the city of Saitama, in Saitama Prefecture, Japan, and is located in the southwestern part of the city. As of 1 March 2021, the ward had an estimated population of 95,829 and a population density of 5,100 persons per km². Its total area was 18.64 square kilometres (7.20 sq mi).