The Saleen S281 is a variant introduced between the 4th and 5th generations of Ford Mustang which was produced by the American manufacturer Saleen, Inc. By 2005, Saleen departed from being a company of modifying existing Ford Mustangs as well as various other Ford automobiles, and became an Original equipment manufacturer. This was easily distinguishable with the bodywork designed by Phil Frank on the S-281's as well as the various other models offered by Saleen.

Saleen Automotive, Inc., commonly known as Saleen (/səˈliːn/), is an American manufacturer of specialty high-performance sports cars and high-performance automotive parts. Saleen is headquartered in Corona, California, USA and privately held.