Saline County is a county in Southern Illinois. At the 2020 census, it had a population of 23,768. The largest city and county seat is Harrisburg. This area of Southern Illinois is known locally as "Little Egypt".

Southern Illinois is a region of the U.S. state of Illinois comprising the southern third of the state, principally south of Interstate 70. Part of downstate Illinois, it is bordered by the two most voluminous rivers in the United States: the Mississippi below its connection with the Missouri River to the west and the Ohio River to the east and south, with the Wabash as a tributary. Some areas of Southern Illinois are known historically as Little Egypt.