Salisbury is a city in and the county seat of Wicomico County, Maryland, United States. Salisbury is the largest city in the state's Eastern Shore region, with a population of 33,050 at the 2020 census. Salisbury is the principal city of the Salisbury, Maryland-Delaware Metropolitan Statistical Area. The city is the commercial hub of the Delmarva Peninsula, which was long devoted to agriculture and had a southern culture. It calls itself "The Comfortable Side of Coastal".

Wicomico County is located in the southeastern part of the U.S. state of Maryland, on the Delmarva Peninsula. As of the 2020 census, the population was 103,588. The county seat is Salisbury. The county was named for the Wicomico River, which in turn derives its name from the Algonquian language words wicko mekee, meaning "a place where houses are built," apparently referring to a Native American town on the banks. The county is included in the Salisbury, MD-DE Metropolitan Statistical Area.