Wicomico County is located in the southeastern part of the U.S. state of Maryland, on the Delmarva Peninsula. As of the 2020 census, the population was 103,588. The county seat is Salisbury. The county was named for the Wicomico River, which in turn derives its name from the Algonquian language words wicko mekee, meaning "a place where houses are built," apparently referring to a Native American town on the banks. The county is included in the Salisbury, MD-DE Metropolitan Statistical Area.

The Delmarva Peninsula, or simply Delmarva, is a large peninsula on the East Coast of the United States, occupied by the vast majority of the state of Delaware and parts of the Eastern Shore of Maryland and Eastern Shore of Virginia.