Salyut 1 (DOS-1) was the world's first space station launched into low Earth orbit by the Soviet Union on April 19, 1971. The Salyut program followed this with five more successful launches of seven more stations. The final module of the program, Zvezda (DOS-8), became the core of the Russian segment of the International Space Station and remains in orbit.

Mir was a space station that operated in low Earth orbit from 1986 to 2001, operated by the Soviet Union and later by Russia. Mir was the first modular space station and was assembled in orbit from 1986 to 1996. It had a greater mass than any previous spacecraft. At the time it was the largest artificial satellite in orbit, succeeded by the International Space Station (ISS) after Mir's orbit decayed. The station served as a microgravity research laboratory in which crews conducted experiments in biology, human biology, physics, astronomy, meteorology, and spacecraft systems with a goal of developing technologies required for permanent occupation of space.