Samuel Alexander Mudd Sr. was an American physician who was imprisoned for conspiring with John Wilkes Booth concerning the assassination of Abraham Lincoln.

On April 14, 1865, Abraham Lincoln, the 16th president of the United States, was assassinated by John Wilkes Booth while attending the play Our American Cousin at Ford's Theatre in Washington, D.C. Shot in the head as he watched the play, Lincoln died of his wounds the following day at 7:22 am in the Petersen House opposite the theater. He was the first U.S. president to be assassinated. His funeral and burial were marked by an extended period of national mourning.