San Angelo is a city in and the county seat of Tom Green County, Texas, United States. Its location is in the Concho Valley, a region of West Texas between the Permian Basin to the northwest, Chihuahuan Desert to the southwest, Osage Plains to the northeast, and Central Texas to the southeast. According to the 2020 United States Census, San Angelo had a total population of 99,893. It is the principal city and center of the San Angelo metropolitan area, which had a population of 121,516.

Tom Green County is a county located on the Edwards Plateau in the U.S. state of Texas. As of the 2020 census, its population was 120,003. Its county seat is San Angelo. The county was created in 1874 and organized the following year. It is named for Thomas Green, who was a Confederate soldier and lawyer. Tom Green County is included in the San Angelo metropolitan statistical area; the county is home to Goodfellow Air Force Base, as well as Angelo State University, part of the Texas Tech University System.