The San Angelo metropolitan statistical area (MSA) is a metropolitan area in West Texas that covers two counties - Tom Green and Irion. As of the 2010 census, the MSA had a population of 111,823, with a 2014 estimate of 118,182.

Irion County is a county located on the Edwards Plateau in the U.S. state of Texas. As of the 2020 census, its population was 1,513. Its county seat is Mertzon. The county is named for Robert Anderson Irion, a secretary of state of the Republic of Texas.