San Diego is a city on the Pacific Ocean coast in Southern California located immediately adjacent to the Mexico–United States border. With a population of over 1.3 million residents, the city is the eighth-most populous in the United States and the second-most populous in the state of California after Los Angeles. The city is the seat of San Diego County, which has a population of nearly 3.3 million people as of 2021. San Diego is known for its mild year-round Mediterranean climate, extensive beaches and parks, its long association with the United States Navy, and its recent emergence as a healthcare and biotechnology development center.

Southern California is a geographic and cultural region that generally comprises the southern portion of the U.S. state of California. It includes the Los Angeles metropolitan area as well as the Inland Empire. The region generally contains ten of California's 58 counties: Imperial, Kern, Los Angeles, Orange, Riverside, San Bernardino, San Diego, Santa Barbara, San Luis Obispo and Ventura counties.