The Church of Saint Francis of Assisi is a Gothic-style, Roman Catholic church of Palermo. It is located near a major and ancient street of the city, via Cassaro, in the quarter of the Kalsa, within the historic centre of Palermo. The building represents the main Conventual Franciscan church of Sicily, and has the title of minor basilica.

Kalsa or Mandamento Tribunali is a historical quarter of the Italian city of Palermo in Sicily. It is sometimes referred to as la Kalsa or the Kalsa.