San Francisco de Macorís is a city in the Dominican Republic located in the northeast portion of the island, in the Cibao region. It is the capital of the Duarte Province and the sixth most populated city in the country. The name San Francisco de Macorís comes from a combination of the name of Saint Francis, patron saint of the Franciscan Order and the territory's old name, which is Macorix.

Duarte is a northeastern province which comprises one of the 32 provinces of the Dominican Republic. It is divided into 7 municipalities and its capital city is San Francisco de Macorís. It is bordered by the provinces of María Trinidad Sánchez and Samaná to the east, Monte Plata and Sánchez Ramírez to the south, La Vega and Hermanas Mirabal to the west and Espaillat to the north. It is named after Juan Pablo Duarte, the founder of the Dominican Republic.