San Francisco de Macorís is a city in the Dominican Republic located in the northeast portion of the island, in the Cibao region. It is the capital of the Duarte Province and the sixth most populated city in the country. The name San Francisco de Macorís comes from a combination of the name of Saint Francis, patron saint of the Franciscan Order and the territory's old name, which is Macorix.

The Cibao, usually referred as "El Cibao", is a region of the Dominican Republic located at the northern part of the country. As of 2009 the Cibao has a population of 5,622,378 making it the most populous region in the country.