San Girolamo della Carità is a church in Rome, Italy, located near the Palazzo Farnese and Campo de' Fiori.

The Last Communion of St. Jerome is a 1614 oil-on-canvas painting by the Italian artist Domenichino. It was commissioned for the church of San Girolamo della Carità in Rome in 1612 and is now in the Pinacoteca Vaticana. The composition is very similar to a painting of the same subject by Agostino Carracci. Domenichino's rival, Giovanni Lanfranco, accused Domenichino of plagiarism due to the similarities.