San Ignacio de Moxos is a town in the Beni Department of northern Bolivia.

The Villa Tunari – San Ignacio de Moxos Highway, also known as the Cochabamba–Beni Highway is a road project in Bolivia connecting the towns of Villa Tunari and San Ignacio de Moxos. It would provide the first direct highway link between the two departments. The project has an expected overall cost of $415 million and extends 306 kilometres (190 mi), divided into three segments: Segment I from Villa Tunari to Isinuta, Segment II from Isinuta to Monte Grande, and Segment III from Monte Grande to San Ignacio de Moxos. Opposition to the highway by local indigenous communities, environmentalists, as well as shifting relations between the Bolivian government and the project's builders and funders interrupted construction of Segment I from October 2011 until October 2013, indefinitely delayed Segment II, and postponed construction of Segment III until June 2015. Segment II will proceed after the government has promised to raise living standards in the area.