San Luis is a statutory town that is the county seat and the most populous town of Costilla County, Colorado, United States. Formerly known as San Luis de la Culebra, it is the oldest continuously occupied town in Colorado. The population was 598 at the 2020 census.

Costilla County is a county located in the U.S. state of Colorado. As of the 2020 census, the population was 3,499. The county seat is San Luis, the oldest continuously occupied town in Colorado.