San Luis Obispo Coast and SLO Coast identify the sixteenth American Viticultural Area (AVA) within San Luis Obispo County, California. It was established by the Alcohol and Tobacco Tax and Trade Bureau (TTB), Treasury on April 8, 2022, becoming the state's 143rd official AVA. The area encompasses over 480,585 acres (750.914 sq mi) nestled between the Santa Lucia mountains and the Pacific coastline stretching about 70 miles (110 km) from Ragged Point southbound on the Pacific Coast Highway (PCH) and Highway 101 to the outskirts of Santa Maria at the intersection of State Highway 166 and Highway 101. It includes the coastal communities of San Simeon, Cambria, Cayucos, Morro Bay, Avila Beach, Pismo Beach, Arroyo Grande and Nipomo while encompassing the county seat of San Luis Obispo. The TTB approved the petition's two names, "San Luis Obispo Coast" and "SLO Coast", to identify the viticultural area's description and wine labeling. The term "SLO" is a historical and commonly used reference for the county and city initials as well as a description of the region's relaxed culture. The new AVA overlaps the previously established Edna Valley and Arroyo Grande Valley viticultural areas. There are over 50 wineries and an estimated 78 commercial vineyards cultivating approximately 3,942 acres (1,595 ha) with a majority of the vineyards located within 6 miles (9.7 km) of the Pacific Ocean defining an area whose grapes and wines represent it. Cool weather varietals like Pinot Noir and Chardonnay are commonly grown while lesser varietals Sauvignon Blanc, Gewürztraminer and Gruner Veltliner also thrive.

Central Coast is a vast American Viticultural Area (AVA) that spans along the Central California Pacific coastline from the San Francisco Bay Area south through Monterey, San Luis Obispo and Santa Barbara Counties. It was established on November 25, 1985 by the Bureau of Alcohol, Tobacco and Firearms (ATF), Treasury after reviewing the petition submitted by Taylor California Cellars, a winery in Gonzales, California, to establish the "Central Coast" viticultural area. The boundaries of the Central Coast, which have been expanded twice, includes portions of six counties where approximately 100,000 acres (40,469 ha) cultivated with Chardonnay being more than half of the varietal. Within the multi-county AVA are numerous established appellations that share the same maritime climate produced by the Pacific Ocean.